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      Deep learning for acute rib fracture detection in CT data: a systematic review and meta-analysis

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          Abstract

          Objectives

          To review studies on deep learning (DL) models for classification, detection, and segmentation of rib fractures in CT data, to determine their risk of bias (ROB), and to analyse the performance of acute rib fracture detection models.

          Methods

          Research articles written in English were retrieved from PubMed, Embase, and Web of Science in April 2023. A study was only included if a DL model was used to classify, detect, or segment rib fractures, and only if the model was trained with CT data from humans. For the ROB assessment, the Quality Assessment of Diagnostic Accuracy Studies tool was used. The performance of acute rib fracture detection models was meta-analysed with forest plots.

          Results

          A total of 27 studies were selected. About 75% of the studies have ROB by not reporting the patient selection criteria, including control patients or using 5-mm slice thickness CT scans. The sensitivity, precision, and F1-score of the subgroup of low ROB studies were 89.60% (95%CI, 86.31%-92.90%), 84.89% (95%CI, 81.59%-88.18%), and 86.66% (95%CI, 84.62%-88.71%), respectively. The ROB subgroup differences test for the F1-score led to a p-value below 0.1.

          Conclusion

          ROB in studies mostly stems from an inappropriate patient and data selection. The studies with low ROB have better F1-score in acute rib fracture detection using DL models.

          Advances in knowledge

          This systematic review will be a reference to the taxonomy of the current status of rib fracture detection with DL models, and upcoming studies will benefit from our data extraction, our ROB assessment, and our meta-analysis.

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          Most cited references53

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          The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

          The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, published in 2009, was designed to help systematic reviewers transparently report why the review was done, what the authors did, and what they found. Over the past decade, advances in systematic review methodology and terminology have necessitated an update to the guideline. The PRISMA 2020 statement replaces the 2009 statement and includes new reporting guidance that reflects advances in methods to identify, select, appraise, and synthesise studies. The structure and presentation of the items have been modified to facilitate implementation. In this article, we present the PRISMA 2020 27-item checklist, an expanded checklist that details reporting recommendations for each item, the PRISMA 2020 abstract checklist, and the revised flow diagrams for original and updated reviews.
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            QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies.

            In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.
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              Risk‐of‐bias VISualization (robvis): An R package and Shiny web app for visualizing risk‐of‐bias assessments

              Despite a major increase in the range and number of software offerings now available to help researchers produce evidence syntheses, there is currently no generic tool for producing figures to display and explore the risk-of-bias assessments that routinely take place as part of systematic review. However, tools such as the R programming environment and Shiny (an R package for building interactive web apps) have made it straightforward to produce new tools to help in producing evidence syntheses. We present a new tool, robvis (Risk-Of-Bias VISualization), available as an R package and web app, which facilitates rapid production of publication-quality risk-of-bias assessment figures. We present a timeline of the tool's development and its key functionality.
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                Author and article information

                Contributors
                Journal
                Br J Radiol
                Br J Radiol
                bjr
                The British Journal of Radiology
                Oxford University Press
                0007-1285
                1748-880X
                March 2024
                13 January 2024
                13 January 2024
                : 97
                : 1155
                : 535-543
                Affiliations
                University Centre of Legal Medicine Lausanne-Geneva , Geneva 1206, Switzerland
                University Hospital and University of Geneva , Geneva 1205, Switzerland
                University Centre of Legal Medicine Lausanne-Geneva , Geneva 1206, Switzerland
                University Hospital and University of Geneva , Geneva 1205, Switzerland
                University Hospital and University of Lausanne , Lausanne 1005, Switzerland
                Department of Computer Science, Viper Group, University of Geneva , Carouge 1227, Switzerland
                University Centre of Legal Medicine Lausanne-Geneva , Geneva 1206, Switzerland
                University Hospital and University of Geneva , Geneva 1205, Switzerland
                University Hospital and University of Lausanne , Lausanne 1005, Switzerland
                Author notes
                Corresponding author: Manel Lopez-Melia, MS, University Centre of Legal Medicine Lausanne-Geneva, Rue Michel-Servet 1, Geneva 1206, Switzerland ( manel.lopezmelia@ 123456unige.ch )
                Author information
                https://orcid.org/0009-0004-5195-2543
                Article
                tqae014
                10.1093/bjr/tqae014
                11027249
                38323515
                10f68987-1a6a-4825-be3d-3617e87557bc
                © The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 12 September 2023
                : 16 December 2023
                : 12 January 2024
                : 07 February 2024
                Page count
                Pages: 9
                Funding
                Funded by: Consortium of Swiss Academic Libraries;
                Award ID: 82918619
                Categories
                Systematic Review
                Bjr/Ai-Ml
                Bjr/Resp-Trct
                Bjr/Musc
                AcademicSubjects/MED00870

                Radiology & Imaging
                rib fracture,ct,computed tomography,deep learning
                Radiology & Imaging
                rib fracture, ct, computed tomography, deep learning

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