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      Young's modulus of collagen at slow displacement rates.

      1 , ,
      Bio-medical materials and engineering
      IOS Press

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          Abstract

          Collagen is a key structural component of extracellular matrix and its mechanical properties, particularly its stiffness, have been shown to influence cell function. This study explores the mechanical behavior of type I collagen gels at low rates relevant to that of cell motion. The Young's modulus, E, was obtained for collagen samples of concentrations 1.3, 2 and 3 mg/ml at varying crosshead displacement rates: 0.01, 0.1 and 1 mm/min. Local strain measurement in the gage section were used for both the strain and strain rate determination. The power law models for the modulus at these low strain rates show that the values converge as the displacement rate approaches a quasistatic state. This study provides data that was unavailable in the past on the Young's modulus of collagen at rates relevant to the cell.

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          Author and article information

          Journal
          Biomed Mater Eng
          Bio-medical materials and engineering
          IOS Press
          1878-3619
          0959-2989
          2010
          : 20
          : 6
          Affiliations
          [1 ] Material Science Program, University of Wisconsin-Madison, 1500 Engineering Drive, Madison, WI 53706, USA.
          Article
          9N12R58205XWM333
          10.3233/BME-2010-0649
          21263182
          0d555472-8a78-4c08-b889-fbcd86994d68
          History

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