Mechanisms of the factor V Leiden paradox.

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Abstract

Carriers of the factor V Leiden mutation (FVL-carriers) have a substantially increased risk of deep venous thrombosis (DVT), whereas the risk of pulmonary embolism (PE) is only mildly increased compared with noncarriers. So far few studies have investigated possible mechanisms for this so-called FVL paradox.

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Journal

Journal ID (iso-abbrev): Arterioscler. Thromb. Vasc. Biol.

Title: Arteriosclerosis, thrombosis, and vascular biology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4636

ISSN (Print): 1079-5642

Publication date (Electronic): Oct 2008

Volume: 28

Issue: 10

Affiliations

[1 ] Department of Clinical Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Article

Publisher Item ID: ATVBAHA.108.169524

DOI: 10.1161/ATVBAHA.108.169524

PubMed ID: 18617648

SO-VID: 0b348eee-a409-4416-b6c1-258b93b91ec7

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