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      Erratum to miR-499a-5p promotes 5-FU resistance and the cell proliferation and migration through activating PI3K/Akt signaling by targeting PTEN in pancreatic cancer

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      Editorial Office
      Annals of Translational Medicine
      AME Publishing Company

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          Abstract

          In the article entitled “MiR-499a-5p promotes 5-FU resistance and the cell proliferation and migration through activating PI3K/Akt signaling by targeting PTEN in pancreatic cancer” (1), there are some errors. Firstly, the 7th author “Hao Zheng” should be removed from the authorship and Xian-Gui Hu’s email is incorrect. The authors regret the error due to a lack of communication before publication by listing Hao Zheng in the authorship without his consent. Therefore, the authors’ information should be corrected as follows: The authorship, affiliation and author contribution should be corrected as Liu Ouyang1#, Ren-Dong Liu2#, De-Qiao Lei3#, Qing-Chao Shang4#, Hui-Fen Li5, Xian-Gui Hu1, Gang Jin1 1Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China; 2Department of Hepatobiliary Surgery, General Hospital of Southern Theatre Command, Guangzhou, China; 3Department of General Surgery, General Hospital of Southern Theatre Command, Guangzhou, China; 4Department of Radiation Oncology, General Hospital of Southern Theatre Command, Guangzhou, China; 5Department of Hepatic Surgery & Interventional Radiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China #These authors contributed equally to this work. Contributions: (I) Conception and design: G Jin; (II) Administrative support: L Ouyang, RD Liu, DQ Lei, QC Shang; (III) Provision of study materials or patients: HF Li; (IV) Collection and assembly of data: L Ouyang; (V) Data analysis and interpretation: L Ouyang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Gang Jin; Xian-Gui Hu. Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200438, China. Email: jingang@smmu.edu.cn; hxiangui@126.com/huxg88@hotmail.com. Secondly, in the section of Methods-Real-time quantitative polymerase chain reaction (qRT-PCR), “miR-2053 expression” should be corrected to “miR-499a-5p expression”. Thirdly, in Table 1, column 1, rows 9 “Rectum” should be corrected to “head”; column 1, rows 10 “Colon” should be corrected to “body and Tail”. The authors confirmed the above errors did not affect either the results or the conclusions of the paper. Click here to view the updated version of the article.

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          MiR-499a-5p promotes 5-FU resistance and the cell proliferation and migration through activating PI3K/Akt signaling by targeting PTEN in pancreatic cancer

          Background Pancreatic cancer (PC) can be considered a representative cancer type of the human body. As demonstrated by some studies, microRNA (miR)-499 is dysregulated in various cancer types including PC, for which chemotherapy involving 5-fluorouracil (5-FU) has long been considered the first-line therapy. However, there are complex and comprehensive mechanisms related to 5-FU, which have not been fully elucidated. This study thus aimed to examine the molecular mechanisms of 5-FU resistance through miR-499a-5p in PC. Methods The expression of miR-499a-5p in PC was measured using quantitative polymerase chain reaction (PCR). MiR-499a-5p was examined in-vivo for its effects on the malignant phenotypes of PC cells. Results The results of the present study demonstrated miR-499a-5p to be upregulated in PC and 5-FU resistant PC tissues. According to in vitro assays in PC cells (PANC1/FR), miR-499a-5p was found to affect adenosine triphosphate (ATP) binding cassette subfamily B member 1 (P-gp), ATP binding cassette subfamily C member 1 (MRP1), and ATP binding cassette subfamily G member 2 (BCRP), thereby facilitating 5-FU resistance in PC cells. Functions assays indicated that suppressed miR-499a-5p expression inhibited the proliferation and migration of cells but facilitated apoptosis in the PC cell line; by contrast, miR-499a-5p overexpression triggered the inverse phenotypic changes of cells. Concerning the mechanisms involved, miR-499a-5p increased PI3K/Akt signaling by targeting phosphatase and tensin homolog (PTEN). Conclusions Taken together, these findings demonstrate that miR-499a-5p can be potentially applied to PC therapy.
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            Author and article information

            Journal
            Ann Transl Med
            Ann Transl Med
            ATM
            Annals of Translational Medicine
            AME Publishing Company
            2305-5839
            2305-5847
            June 2022
            June 2022
            June 2022
            : 10
            : 11
            : 651
            Affiliations
            [1]Annals of Translational Medicine
            Author notes
            Correspondence to: Editorial Office. Annals of Translational Medicine. Email: editor@ 123456atmjournal.org .
            Article
            atm-10-11-651
            10.21037/atm-2022-15
            9263791
            35813318
            0aefbb68-f360-4726-a70e-f05a175ef5df
            2022 Annals of Translational Medicine. All rights reserved.

            Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

            History
            : 19 April 2022
            : 29 April 2022
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