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      Infantile Hemangioma: A Brief Review

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          Abstract

          Infantile hemangiomas as frequent infancy tumors have been a controversial issue of medical scientists worldwide. Their clinical aspects are various and their physiopathology is yet to be fully understood. Numerous publications outline the characteristics, causes, evolution possibilities and therapeutic approaches. Deciding whether to treat or not is the main question of this kind of pathology. Hemangiomas that have complications or can cause irreversible damage need therapy. This is a brief review of up-to-date information regarding the presentation of infantile hemangiomas and target-therapies.

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          Propranolol and infantile hemangiomas four years later: a systematic review.

          Ann L Marqueling, Vikash Oza, Ilona Frieden … (2015)
          To systematically review the literature evaluating efficacy and adverse events of propranolol treatment for infantile hemangiomas, we searched the MEDLINE and Cochrane databases for all studies examining the response of infantile hemangiomas (IHs) to propranolol published between June 12, 2008, and June 15, 2012. Forty-one studies with 1,264 patients were included; 74% of patients were female and approximately 30% had received other treatments before propranolol. Propranolol was initiated at a mean age of 6.6 months at a mean dose of 2.1 mg/kg/day and for a mean treatment duration of 6.4 months. The response rate for patients with IHs treated with propranolol was 98% (range 82%-100%), with response rate defined as any improvement with propranolol. Treatment response rates were comparable for studies evaluating IHs at specific sites, such as periorbital IHs. Studies that followed patients after treatment completion reported IH rebound growth in 17% of patients. There were 371 adverse events reported in 1,189 patients. The most common adverse events were changes in sleep (n = 136) and acrocyanosis (n = 61). Serious adverse events were rare, with reports of symptomatic hypotension in five patients, hypoglycemia in four, and symptomatic bradycardia in one. This systematic review of 1,264 patients treated with propranolol for IHs showed a high rate of efficacy and a low rate of serious adverse events. © 2013 Wiley Periodicals, Inc.
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            Infantile hemangiomas: an emerging health issue linked to an increased rate of low birth weight infants.

            Beth Drolet, Elizabeth A Swanson, Ilona Frieden (2008)
            A total of 420 children with infantile hemangioma (IH) were compared with 353 age-matched controls. Using multivariate logistic regression, low birth weight was the most significant risk factor; for every 500-g decrease in birth weight, the risk of IH increased by 40%. A positive family history also increased the risk of IH (33% vs 15% of controls; P < .001).
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              Propranolol-resistant infantile haemangiomas.

              C Chiaverini, S Causse, J Mazereeuw-Hautier … (2013)
              Propranolol is now widely used to treat severe infantile haemangiomas (IHs). Very few cases of propranolol-resistant IH (PRIH) are mentioned in the literature. To describe the characteristics of PRIHs. A national, multicentre, retrospective, observational study was conducted from February 2011 to December 2011. All patients with PRIH evaluated by the members of the Groupe de Recherche Clinique en Dermatologie Pédiatrique from 1 January 2007 to 1 December 2011 were eligible. Among 1130 patients treated with propranolol for infantile haemangioma, 10 (0.9%) had PRIHs. Haemangioma propranolol resistance was observed at all ages during early childhood and at any proliferation stage. PRIH is a rare phenomenon that raises questions and merits further investigation. © 2013 British Association of Dermatologists.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Clujul Med
                Journal ID (iso-abbrev): Clujul Med
                Journal ID (publisher-id): CM
                Title: Clujul Medical
                Publisher: Iuliu Hatieganu University of Medicine and Pharmacy
                ISSN (Print): 1222-2119
                ISSN (Electronic): 2066-8872
                Publication date (Print): 2015
                Publication date (Electronic): 28 January 2015
                Volume: 88
                Issue: 1
                Pages: 23-27
                Affiliations
                [1 ]Department of Pediatrics II, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
                [2 ]Department of Dermatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
                Author notes
                Address for correspondence: Madalina.Bota@ 123456umfcluj.ro
                Article
                Publisher ID: cm8801p23
                DOI: 10.15386/cjmed-381
                PMC ID: 4508608
                PubMed ID: 26528043
                SO-VID: 07c0cedd-ddd5-467c-b95b-5568e46b6193
                Copyright statement: Copyright @ 2015
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

                History
                Date received : 12 December 2014
                Date accepted : 29 December 2014
                Categories
                Subject: Review
                Subject: Pediatrics

                Keywords: infantile hemangiomas,etiopathogenesis,therapy
                Data availability:
                Keywords: infantile hemangiomas, etiopathogenesis, therapy

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