A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.

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Abstract

Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A previous phase II study suggested possible clinical benefit.

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Author and article information

Journal

Journal ID (iso-abbrev): JAMA Neurol

Title: JAMA neurology

Publisher: American Medical Association (AMA)

ISSN (Electronic): 2168-6157

ISSN (Print): 2168-6149

Publication date (Electronic): May 2014

Volume: 71

Issue: 5

Affiliations

[1 ] Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.

[2 ] Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.

[3 ] Department of Neurology, Georgetown University, Washington, DC.

[4 ] National Institutes of Health, Bethesda, Maryland.

[5 ] Department of Neurosciences, University of California, San Diego, La Jolla.

[6 ] Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia.

[7 ] Department of Neurology, Oregon Health and Science University, Portland.

[8 ] Merck, New Jersey.

[9 ] Biogen Idec, Cambridge, Massachusetts.

[10 ] Department of Neurosciences, University of California, San Diego, La Jolla10VA Medical Center, San Diego, California.

[11 ] Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles.

[12 ] Department of Biostatistics, University of Rochester Medical Center, Rochester, New York12Department of Neurology, University of Rochester, Rochester, New York.

[13 ] Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada.

[14 ] Rush University Medical Center, Chicago, Illinois.

[15 ] Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington.

[16 ] London Health Sciences Centre, London, Ontario, Canada.

[17 ] Overlook Medical Center, Atlantic Neuroscience Institute, Summit, New Jersey.

[18 ] Department of Neurology, University of Rochester, Rochester, New York.

[19 ] Columbia University Medical Center, Neurological Institute, New York, New York.

[20 ] Department of Neurology, University of Texas Health Science Center at Houston.

[21 ] Department of Neurology, Baylor College of Medicine, Houston, Texas.

[22 ] Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

[23 ] The Parkinson's Institute and Clinical Center, Sunnyvale, California.

[24 ] Department of Neurology, University of Miami School of Medicine, Miami, Florida.

[25 ] Institute for Neurodegenerative Disorders, New Haven, Connecticut.

[26 ] Department of Neurology, Butler Hospital, Providence, Rhode Island26Alpert Medical School, Brown University, Providence, Rhode Island.

[27 ] Department of Neurology, Butler Hospital, Providence, Rhode Island27Port City Neurology, Inc, Scarborough, Maine.

[28 ] Department of Neurology, University of California, Davis, School of Medicine and Sacramento VA Medical Center, Sacramento.

[29 ] Port City Neurology, Inc, Scarborough, Maine.

[30 ] Colorado Neurological Institute, Englewood.

[31 ] Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey.

[32 ] Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.

[33 ] Avid Radiopharmaceuticals, Philadelphia, Pennsylvania.

[34 ] Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia33Atlanta VA Medical Center, Atlanta, Georgia.

[35 ] Muhammad Ali Parkinson Center, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona.

[36 ] Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.

[37 ] Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada.

[38 ] Department of Neurology, University of Alabama at Birmingham.

[39 ] Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.

[40 ] Department of Neurology, Johns Hopkins University, Baltimore, Maryland.

[41 ] Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York.

[42 ] Department of Neurology, New York University Langone Medical Center, New York.

[43 ] Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

[44 ] The Parkinson's and Movement Disorder Institute, Fountain Valley, California.

[45 ] State University of New York, Downstate Medical Center, Brooklyn, New York.

[46 ] Department of Neurology, University of South Florida, Tampa.

[47 ] Department of Neurology, University of Kansas Medical Center, Kansas City.

[48 ] Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

[49 ] Department of Neurology, Georgia Health Science University, Augusta.

[50 ] Department of Neurology, University of Louisville, Kentucky.

[51 ] University of Cincinnati College of Medicine, Cincinnati, Ohio.

[52 ] Department of Neurology, Medical University of South Carolina, Charleston.

[53 ] Associated Neurologists, PC, Danbury, Connecticut.

[54 ] Department of Neurology, Washington University in St Louis, Missouri.

[55 ] Movement Disorders Center, Albany Medical Center, Albany, New York.

[56 ] Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.

[57 ] Center for Neurological Health, University of Toledo, Toledo, Ohio.

[58 ] Department of Neurology, Medical University of Ohio at Toledo.

[59 ] Department of Neurology, University of Colorado Health Science Center, Denver.

[60 ] Department of Neurology, University of California, Irvine Medical Center, Irvine.

[61 ] Banner Sun Health Research Institute, Sun City, Arizona.

[62 ] Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada.

[63 ] Department of Neurology, University of California, San Diego, La Jolla.

[64 ] Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

[65 ] Department of Neurology, Medical College of Wisconsin, Milwaukee.

[66 ] Department of Neurology, Duke University, Durham, North Carolina.

[67 ] State University of New York Upstate Medical Center and Syracuse VA Medical Center, Syracuse.

[68 ] Department of Neurology, University of Iowa, Iowa City.

[69 ] Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.

[70 ] Department of Neurology, University of Vermont College of Medicine, Burlington.

[71 ] Department of Neurology, Ohio State University, Columbus.

[72 ] Department of Neurology, Indiana University School of Medicine, Indianapolis.

[73 ] Department of Neurology, University of Tennessee Health Science Center, Memphis.

[74 ] Department of Neurology, CHUM-Hôpital Notre-Dame, Montréal, Québec, Canada.

[75 ] Department of Neurology, University of Maryland School of Science, Baltimore.

[76 ] Department of Neurology, University of Sherbrooke, Québec, Canada.

[77 ] Department of Neurology, Louisiana State University Health Science Center, Shreveport.

[78 ] Lewis Hall Singletary Oncology Center, Thomasville, Georgia.

[79 ] Parkinson and Movement Disorders Center of Maryland, Elkridge.

[80 ] Department of Neurology, University of Minnesota, Minneapolis.

[81 ] Department of Neurology, University of Chicago, Chicago, Illinois.

[82 ] Department of Neurology, Ochsner Clinic Foundation, New Orleans, Louisiana.

[83 ] Department of Neurology, Beth Israel Medical Center, New York, New York.

Article

Publisher Item ID: 1851409

DOI: 10.1001/jamaneurol.2014.131

PubMed ID: 24664227

SO-VID: 06525eb8-94d7-40da-9966-3f37872ccc9c

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