Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

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Abstract

The convergence of end-to-end continuous flow synthesis with downstream processing, process analytical technology (PAT), artificial intelligence (AI), machine learning and automation in ensuring improved accessibility of quality medicines on demand.

Abstract

Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical ingredients (APIs), inline flow downstream processing, in-process monitoring by process analytical technology (PAT) in flow, flow automation and artificial intelligence (AI) and robotics. We envisage that the integration of all these techniques can ensure an ‘ideal’ smart and efficient 21st century API chemical process that dramatically improves efficiency, agility, quality and flexibility in the manufacturing of pharmaceuticals.

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Author and article information

Contributors

Cloudius R. Sagandira: (View ORCID Profile)

Paul Watts: (View ORCID Profile)

Journal

Journal ID (publisher-id): RCEEBW

Title: Reaction Chemistry & Engineering

Abbreviated Title: React. Chem. Eng.

Publisher: Royal Society of Chemistry (RSC)

ISSN (Electronic): 2058-9883

Publication date Created: February 01 2022

Publication date (Electronic): 2022

Volume: 7

Issue: 2

Pages: 214-244

Affiliations

[1 ]Nelson Mandela University, University Way, Port Elizabeth, 6031, South Africa

Article

DOI: 10.1039/D1RE00483B

SO-VID: 0631acd7-aaae-4865-9595-2ac4734cc833

License:

http://rsc.li/journals-terms-of-use

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