The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication.

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Abstract

Recombinant adeno-associated virus (rAAV) is now in the clinic, yet production of rAAV remains problematic. We previously determined that human papillomavirus type 16 (HPV16) E1 protein boosts rAAV yields and E1 enhances AAV Rep78's replication-related biochemistries. Here, we deletion-mapped the helper domain within E1 to help glean its mechanism of action.

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Author and article information

Journal

Journal ID (iso-abbrev): Intervirology

Title: Intervirology

Publisher: S. Karger AG

ISSN (Electronic): 1423-0100

ISSN (Print): 0300-5526

Publication date (Electronic): 2018

Volume: 61

Issue: 4

Affiliations

[1 ] Departments of Obstetrics and Gynecology and Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

[2 ] Beijing Friendship Hospital, Capital Medical University, Beijing, China.

[3 ] Beijing Friendship Hospital, Capital Medical University, Beijing, China, aavguy123@yahoo.com.

[4 ] Departments of Obstetrics and Gynecology and Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA, aavguy123@yahoo.com.

Article

Publisher Item ID: 000495137

DOI: 10.1159/000495137

PubMed ID: 30654371

SO-VID: 041aa273-8d14-4769-a494-9fc79579344f

History

Keywords: Adeno-associated virus,DNA replication,E1 protein,Human papillomavirus type 16,Rep78

Data availability:

Keywords: Adeno-associated virus, DNA replication, E1 protein, Human papillomavirus type 16, Rep78

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