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Recent advances in drug delivery systems for targeting cancer stem cells
review-article
02 October 2020
Cancer stem cells,
Targeting strategies,
Drug delivery systems,
Cancer treatment,
Niche,
Biomarker,
Cellular level,
Molecular level,
ABC, ATP binding cassette,
AFN, apoferritin,
ALDH, aldehyde dehydrogenase,
BM-MSCs-derived Exos, bone marrow mesenchymal stem cells-derived exosomes,
CAFs, cancer-associated fibroblasts,
CL-siSOX2, cationic lipoplex of SOX2 small interfering RNA,
CMP, carbonate-mannose modified PEI,
CQ, chloroquine,
cRGD, cyclic Arg-Gly-Asp,
CSCs, cancer stem cells,
DDSs, drug delivery systems,
DCLK1, doublecortin-like kinase 1,
Dex, dexamethasone,
DLE, drug loading efficiency,
DOX, doxorubicin,
DQA-PEG2000-DSPE, dequlinium and carboxyl polyethylene glycol-distearoylphosphatidylethanolamine,
ECM, extracellular matrix,
EMT, epithelial–mesenchymal transition,
EpCAM, epithelial cell adhesion molecule,
EPND, nanodiamond-Epirubicin drug complex,
GEMP, gemcitabine monophosphate,
Glu, glucose,
GLUT1, glucose ligand to the glucose transporter 1,
HCC, hepatocellular carcinoma,
HH, Hedgehog,
HIF1α, hypoxia-inducible factor 1-alpha,
HNSCC, head and neck squamous cell carcinoma,
IONP, iron oxide nanoparticle,
iTEP, immune-tolerant, elastin-like polypeptide,
LAC, lung adenocarcinoma,
LNCs, lipid nanocapsules,
mAbs, monoclonal antibodies,
MAPK, mitogen-activated protein kinase,
MB, methylene blue,
MDR, multidrug resistance,
MNP, micellar nanoparticle,
mPEG-b-PCC-g-GEM-g-DC-g-CAT, poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylenecarbonate-graft-dodecanol-graft-cationic ligands) ,
MSNs, mesoporous silica nanoparticles,
Nav, navitoclax,
ncRNA, non-coding RNAs,
NF-κB, nuclear factor-kappa B,
PBAEs, poly(β-aminoester),
PDT, photodynamic therapy,
PEG-b-PLA, poly(ethylene glycol)-block-poly(d,l-lactide),
PEG-PCD, poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol),
PEG-PLA, poly(ethylene glycol)-b-poly(d,l-lactide),
PLGA, poly(ethylene glycol)-poly(d,l-lactide-co-glycolide),
PTX, paclitaxel,
PU-PEI, polyurethane-short branch-polyethylenimine,
Sali-ABA, 4-(aminomethyl) benzaldehyde-modified Sali,
SLNs, solid lipid nanoparticles,
SSCs, somatic stem cells,
TNBC, triple negative breast cancer,
TPZ, tirapazamine,
uPAR, urokinase plasminogen activator receptor
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Abstract
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those of normal stem cells. Although few in number, they are capable of self-renewal, unlimited proliferation, and multi-directional differentiation potential. In addition, CSCs have the ability to escape immune surveillance. Thus, they play an important role in the occurrence and development of tumors, and they are closely related to tumor invasion, metastasis, drug resistance, and recurrence after treatment. Therefore, specific targeting of CSCs may improve the efficiency of cancer therapy. A series of corresponding promising therapeutic strategies based on CSC targeting, such as the targeting of CSC niche, CSC signaling pathways, and CSC mitochondria, are currently under development. Given the rapid progression in this field and nanotechnology, drug delivery systems (DDSs) for CSC targeting are increasingly being developed. In this review, we summarize the advances in CSC-targeted DDSs. Furthermore, we highlight the latest developmental trends through the main line of CSC occurrence and development process; some considerations about the rationale, advantages, and limitations of different DDSs for CSC-targeted therapies were discussed.
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Author and article information
cancer stem cells,targeting strategies,drug delivery systems,cancer treatment,niche,biomarker,cellular level,molecular level,abc, atp binding cassette,afn, apoferritin,aldh, aldehyde dehydrogenase,bm-mscs-derived exos, bone marrow mesenchymal stem cells-derived exosomes,cafs, cancer-associated fibroblasts,cl-sisox2, cationic lipoplex of sox2 small interfering rna,cmp, carbonate-mannose modified pei,cq, chloroquine,crgd, cyclic arg-gly-asp,cscs, cancer stem cells,ddss, drug delivery systems,dclk1, doublecortin-like kinase 1,dex, dexamethasone,dle, drug loading efficiency,dox, doxorubicin,dqa-peg2000-dspe, dequlinium and carboxyl polyethylene glycol-distearoylphosphatidylethanolamine,ecm, extracellular matrix,emt, epithelial–mesenchymal transition,epcam, epithelial cell adhesion molecule,epnd, nanodiamond-epirubicin drug complex,gemp, gemcitabine monophosphate,glu, glucose,glut1, glucose ligand to the glucose transporter 1,hcc, hepatocellular carcinoma,hh, hedgehog,hif1α, hypoxia-inducible factor 1-alpha,hnscc, head and neck squamous cell carcinoma,ionp, iron oxide nanoparticle,itep, immune-tolerant, elastin-like polypeptide,lac, lung adenocarcinoma,lncs, lipid nanocapsules,mabs, monoclonal antibodies,mapk, mitogen-activated protein kinase,mb, methylene blue,mdr, multidrug resistance,mnp, micellar nanoparticle,mpeg-b-pcc-g-gem-g-dc-g-cat, poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylenecarbonate-graft-dodecanol-graft-cationic ligands),msns, mesoporous silica nanoparticles,nav, navitoclax,ncrna, non-coding rnas,nf-κb, nuclear factor-kappa b,pbaes, poly(β-aminoester),pdt, photodynamic therapy,peg-b-pla, poly(ethylene glycol)-block-poly(d,l-lactide),peg-pcd, poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol),peg-pla, poly(ethylene glycol)-b-poly(d,l-lactide),plga, poly(ethylene glycol)-poly(d,l-lactide-co-glycolide),ptx, paclitaxel,pu-pei, polyurethane-short branch-polyethylenimine,sali-aba, 4-(aminomethyl) benzaldehyde-modified sali,slns, solid lipid nanoparticles,sscs, somatic stem cells,tnbc, triple negative breast cancer,tpz, tirapazamine,upar, urokinase plasminogen activator receptor
cancer stem cells, targeting strategies, drug delivery systems, cancer treatment, niche, biomarker, cellular level, molecular level, abc, atp binding cassette, afn, apoferritin, aldh, aldehyde dehydrogenase, bm-mscs-derived exos, bone marrow mesenchymal stem cells-derived exosomes, cafs, cancer-associated fibroblasts, cl-sisox2, cationic lipoplex of sox2 small interfering rna, cmp, carbonate-mannose modified pei, cq, chloroquine, crgd, cyclic arg-gly-asp, cscs, cancer stem cells, ddss, drug delivery systems, dclk1, doublecortin-like kinase 1, dex, dexamethasone, dle, drug loading efficiency, dox, doxorubicin, dqa-peg2000-dspe, dequlinium and carboxyl polyethylene glycol-distearoylphosphatidylethanolamine, ecm, extracellular matrix, emt, epithelial–mesenchymal transition, epcam, epithelial cell adhesion molecule, epnd, nanodiamond-epirubicin drug complex, gemp, gemcitabine monophosphate, glu, glucose, glut1, glucose ligand to the glucose transporter 1, hcc, hepatocellular carcinoma, hh, hedgehog, hif1α, hypoxia-inducible factor 1-alpha, hnscc, head and neck squamous cell carcinoma, ionp, iron oxide nanoparticle, itep, immune-tolerant, elastin-like polypeptide, lac, lung adenocarcinoma, lncs, lipid nanocapsules, mabs, monoclonal antibodies, mapk, mitogen-activated protein kinase, mb, methylene blue, mdr, multidrug resistance, mnp, micellar nanoparticle, mpeg-b-pcc-g-gem-g-dc-g-cat, poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylenecarbonate-graft-dodecanol-graft-cationic ligands), msns, mesoporous silica nanoparticles, nav, navitoclax, ncrna, non-coding rnas, nf-κb, nuclear factor-kappa b, pbaes, poly(β-aminoester), pdt, photodynamic therapy, peg-b-pla, poly(ethylene glycol)-block-poly(d,l-lactide), peg-pcd, poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol), peg-pla, poly(ethylene glycol)-b-poly(d,l-lactide), plga, poly(ethylene glycol)-poly(d,l-lactide-co-glycolide), ptx, paclitaxel, pu-pei, polyurethane-short branch-polyethylenimine, sali-aba, 4-(aminomethyl) benzaldehyde-modified sali, slns, solid lipid nanoparticles, sscs, somatic stem cells, tnbc, triple negative breast cancer, tpz, tirapazamine, upar, urokinase plasminogen activator receptor