Inhibition of in vitro cytotoxic effect evoked by Alpinia galanga and Alpinia officinarum on PC - 3 cell line

Abstract

Plants have been a source of medicine and a major resource for health care since ancient times, with some traditional herbal medicines having been in use for more than 2,000 years. Herbs and spices are recommended for prevention and cure of various diseases including cancer. Alpinia galanga and Alpinia officinarum, botanical cousin to ginger was recognized superior in many ways and has been employed in medicine for over a thousand years. Prostate cancer is the most common form of cancer in males and the second leading cause of cancer related death. PC-3 cell line was derived from adenocarcinoma of human prostate. This was assayed for MTT assay on treatment with ethanolic extract of Alpinia galanga and Alpinia officinarum, where in inhibition of the cell growth was noticed. This study was supported by DNA fragmentation where a characteristic DNA laddering was noticed in treated tumor cell line and not in the control.