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      Systematic summary and analysis of Chinese HVAC guidelines coping with COVID-19

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          Abstract

          Heating, Ventilation, and Air-Conditioning (HVAC) system that is almost indispensable service system of modern buildings is recognized as the most important engineering control measure against pandemics. However, the effectiveness of HVAC systems has been questioned on their ability to control airborne transmission. After the outbreak of COVID-19, China has controlled the spread within a relatively short period. Considering the large population, high population density, busy transportation and the overall underdeveloped economy, China’s control measures may have some implications to other countries, especially those with limited resources. This paper intends to provide a systematic summary of Chinese ventilation guidelines issued to cope with COVID-19 transmission. The following three aspects are the main focus of these guidelines: (1) general operation and management schemes of various types of HVAC systems, (2) operation and management schemes of HVAC system in typical types of buildings, and (3) design schemes of HVAC system of makeshift hospitals. In addition, some important differences in HVAC guidelines between China and other countries/institutions are identified and compared, and the possible reasons are discussed. Further discussions are made on the following topics, including the required fresh air supply, the extended operation time, the use of auxiliary equipment, the limited capacity of existing systems, and the use of personalized systems.

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          Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents

          Summary Currently, the emergence of a novel human coronavirus, SARS-CoV-2, has become a global health concern causing severe respiratory tract infections in humans. Human-to-human transmissions have been described with incubation times between 2-10 days, facilitating its spread via droplets, contaminated hands or surfaces. We therefore reviewed the literature on all available information about the persistence of human and veterinary coronaviruses on inanimate surfaces as well as inactivation strategies with biocidal agents used for chemical disinfection, e.g. in healthcare facilities. The analysis of 22 studies reveals that human coronaviruses such as Severe Acute Respiratory Syndrome (SARS) coronavirus, Middle East Respiratory Syndrome (MERS) coronavirus or endemic human coronaviruses (HCoV) can persist on inanimate surfaces like metal, glass or plastic for up to 9 days, but can be efficiently inactivated by surface disinfection procedures with 62–71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite within 1 minute. Other biocidal agents such as 0.05–0.2% benzalkonium chloride or 0.02% chlorhexidine digluconate are less effective. As no specific therapies are available for SARS-CoV-2, early containment and prevention of further spread will be crucial to stop the ongoing outbreak and to control this novel infectious thread.
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            Effects of air temperature and relative humidity on coronavirus survival on surfaces.

            Assessment of the risks posed by severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) on surfaces requires data on survival of this virus on environmental surfaces and on how survival is affected by environmental variables, such as air temperature (AT) and relative humidity (RH). The use of surrogate viruses has the potential to overcome the challenges of working with SARS-CoV and to increase the available data on coronavirus survival on surfaces. Two potential surrogates were evaluated in this study; transmissible gastroenteritis virus (TGEV) and mouse hepatitis virus (MHV) were used to determine effects of AT and RH on the survival of coronaviruses on stainless steel. At 4 degrees C, infectious virus persisted for as long as 28 days, and the lowest level of inactivation occurred at 20% RH. Inactivation was more rapid at 20 degrees C than at 4 degrees C at all humidity levels; the viruses persisted for 5 to 28 days, and the slowest inactivation occurred at low RH. Both viruses were inactivated more rapidly at 40 degrees C than at 20 degrees C. The relationship between inactivation and RH was not monotonic, and there was greater survival or a greater protective effect at low RH (20%) and high RH (80%) than at moderate RH (50%). There was also evidence of an interaction between AT and RH. The results show that when high numbers of viruses are deposited, TGEV and MHV may survive for days on surfaces at ATs and RHs typical of indoor environments. TGEV and MHV could serve as conservative surrogates for modeling exposure, the risk of transmission, and control measures for pathogenic enveloped viruses, such as SARS-CoV and influenza virus, on health care surfaces.
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              Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols

              Infection control instructions call for use of alcohol-based hand rub solutions to inactivate severe acute respiratory syndrome coronavirus 2. We determined the virucidal activity of World Health Organization–recommended hand rub formulations, at full strength and multiple dilutions, and of the active ingredients. All disinfectants demonstrated efficient virus inactivation.
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                Author and article information

                Journal
                Indoor Built Environ
                Indoor Built Environ
                spibe
                IBE
                Indoor + Built Environment
                SAGE Publications (Sage UK: London, England )
                1420-326X
                1423-0070
                May 2022
                May 2022
                May 2022
                : 31
                : 5 , Special Issue - Prevention and control of COVID-19 transmission in the indoor environment
                : 1176-1192
                Affiliations
                [1 ]Department of Building Environment and Energy, College of Civil Engineering, Ringgold 12569, universityHunan University; , Changsha, Hunan, China
                [2 ]National Center for International Research Collaboration in Building Safety and Environment, Ringgold 12569, universityHunan University; , Changsha, Hunan, China
                Author notes
                [*]Zhengtao Ai, Building Environment and Energy, Hunan University, Lushan South Road, Changsha 410082, China. Email: zhengtaoai@ 123456hnu.edu.cn
                Author information
                https://orcid.org/0000-0002-9529-7016
                https://orcid.org/0000-0002-9863-9907
                https://orcid.org/0000-0002-1647-963X
                https://orcid.org/0000-0003-2635-2170
                https://orcid.org/0000-0003-3781-6874
                Article
                10.1177_1420326X211061290
                10.1177/1420326X211061290
                9124639
                0219ac73-9d6b-49d4-b758-ca1eb9d28b89
                © The Author(s) 2022

                This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

                History
                Funding
                Funded by: Fundamental Research Funds for the Central Universities, FundRef https://doi.org/10.13039/501100012226;
                Award ID: 531118010378
                Funded by: National Natural Science Foundation of China, FundRef https://doi.org/10.13039/501100001809;
                Award ID: 51908203
                Categories
                Special Issue - Prevention and control of COVID-19 transmission in the indoor environment
                Custom metadata
                ts10

                covid-19,respiratory infectious diseases,mitigation measures,hvac operation and management,ventilation

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