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      Sleep duration, lifestyles and chronic diseases: a cross-sectional population-based study

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          Abstract

          Background

          Adequate sleep is essential for health. Both, short and long sleep durations are associated to worse quality of life and poor health outcomes. Portugal represents a specific population model, since according to European statistics it has high rates of chronic diseases like depression, hypertension, diabetes and stroke; and low quality of life as well as low index of physical activity, while in parallel it has some other good health indicators such as: low age-standardized mortality for both genders, nutrition in terms of energy and fruit consumption, smoking and alcohol, obesity and overweight prevalence. The aim of this study was to characterize health and chronic diseases, lifestyles and quality of life in subjects with short and long sleep duration.

          Methods

          A population-based cross-sectional evaluation of the third wave of follow-up of the EpiDoC Cohort was carried between 2015-2016. A sample of 5,436 adults ≥18 years, representative of the national population, self-reported their daily total sleep time. Associations between short sleep duration (SSD ≤5h), long sleep duration (LSD≥9h) and independent variables were determined.

          Results

          The prevalence for SSD was high (20.7%) and the LSD (5.9%) was low. Being older, with lower education, retired and unemployed were associated to SSD and LSD ( p<0.01). Being obese was associated to SSD as well as hypertension, gastrointestinal disease and hypercholesterolemia ( p<0.01). SSD and LSD, were associated with diabetes ( p<0.01 and p=0.03) and depression ( p<0.01 and p=0.02) respectively. Cardiovascular disease ( p<0.01) was associated to LSD. Multimorbidity ( p<0.01) was associated to SSD. Worse quality of life and bad physical function were associated to SSD and LSD, as well as being hospitalized in the previous 12 months ( p<0.01).

          Conclusions

          Socio-demographic, physical activity and chronic diseases were associated to reduction and extension of sleep duration. There was no association between rheumatic diseases and cancer with sleep duration, as found in other studies. This study emphasizes the burden of self-reported SSD for Portugal, its consequences to health and the need to increase sleep awareness campaigns enhancing the importance of sleep in health. Furthermore, it emphasizes that chronic diseases risks are dependent on multiple parameters which varying in different countries or regions, imply the need of regional studies and interventions.

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          Most cited references29

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          Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation.

          That insufficient sleep is associated with poor attention and performance deficits is becoming widely recognized. Fewer people are aware that chronic sleep complaints in epidemiologic studies have also been associated with an increase in overall mortality and morbidity. This article summarizes findings of known effects of insufficient sleep on cardiovascular risk factors including blood pressure, glucose metabolism, hormonal regulation, and inflammation with particular emphasis on experimental sleep loss, using models of total and partial sleep deprivation, in healthy individuals who normally sleep in the range of 7 to 8 hours and have no sleep disorders. These studies show that insufficient sleep alters established cardiovascular risk factors in a direction that is known to increase the risk of cardiac morbidity.
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            Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States.

            Research associates short (and to a lesser extent long) sleep duration with obesity, diabetes, and cardiovascular disease; and although 7-8 h of sleep seems to confer the least health risk, these findings are often based on non-representative data. We hypothesize that short sleep ( 8 h) are positively associated with the risk of obesity, diabetes, hypertension, and cardiovascular disease; and analyze 2004-2005 US National Health Interview Survey data (n=56,507 observations, adults 18-85) to test this. We employ multilevel logistic regression, simultaneously controlling for individual characteristics (e.g., ethnoracial group, gender, age, education), other health behaviors (e.g., exercise, smoking), family environment (e.g., income, size, education) and geographic context (e.g., census region). Our model correctly classified at least 76% of adults on each of the outcomes studied, and sleep duration was frequently more strongly associated with these health risks than other covariates. These findings suggest a 7-8 h sleep duration directly and indirectly reduces chronic disease risk. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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              Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN study.

              We studied sleep duration and sleep quality in relation to cardiovascular disease (CVD) incidence. Dutch population-based cohort study. 20,432 men and women aged 20-65 and with no history of CVD. N/A. Sleep duration and sleep quality were assessed by a self-administered questionnaire. Morbidity data, vital status, and causes of death were obtained through linkage with several national registries. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated using Cox proportional hazards models. During 10-15 years of follow-up, 1,486 CVD and 1,148 coronary heart disease (CHD) events occurred. Short sleepers (≤ 6 h) had a 15% higher risk of total CVD (HR: 1.15; 95%CI: 1.00-1.32) and a 23% higher risk of CHD (HR: 1.23 [1.04-1.45]) compared to normal sleepers (7 h) after adjustment for all confounders. Additional adjustment for intermediate biological risk factors attenuated these relative risks to 1.11 (0.97-1.27) for total CVD and to 1.19 (1.00-1.40) for CHD. Short sleepers with poor sleep quality had a 63% higher risk of CVD (HR: 1.63 [1.21-2.19]) and a 79% higher risk of CHD incidence (HR: 1.79 [1.24-2.58]) compared to normal sleepers with good sleep quality, after adjustments for all confounders. We observed no associations between long sleep duration (≥ 9 h) and CVD or CHD incidence. Short sleepers, especially those with poor sleep quality, have an increased risk of total CVD and CHD incidence. Future investigations should not only focus on sleep duration, but should also take sleep quality into account.
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                Author and article information

                Journal
                Sleep Sci
                Sleep Sci
                ssci
                Sleep Science
                Brazilian Association of Sleep and Latin American Federation of Sleep
                1984-0659
                1984-0063
                Jul-Aug 2018
                Jul-Aug 2018
                : 11
                : 4
                : 217-230
                Affiliations
                [1 ] Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto de Saúde Ambiental (ISAMB) - Lisboa - Lisboa - Portugal.
                [2 ] CENC - Sleep Medicine Center, Sleep and circadian rhythms - Lisboa - Lisboa - Portugal.
                [3 ] EpiDoC Unit, NOVA Medical School, Universidade Nova de Lisboa (NMS/UNL), Centro de Estudos de Doenças Crónicas (CEDOC) - Lisboa - Lisboa - Portugal.
                [4 ] Sociedade Portuguesa de Reumatologia, Sociedade Portuguesa de Reumatologia - Lisboa - Lisboa - Portugal.
                [5 ] Instituto de Medicina Molecular, Rheumatology Research Unit - Lisboa - Lisboa - Portugal.
                [6 ] EpiSaúde, Associação Científica - Évora - Évora - Portugal.
                [7 ] Escola Superior de Saúde do Instituto Politécnico de Leiria, CiTechCare, Center for innovative care and health technology - Leiria - Leiria - Portugal.
                [8 ] Direção-Geral da Saúde, Programa Nacional para a Promoção da Alimentação Saudável - Lisboa - Lisboa - Portugal.
                [9 ] Universidade do Porto, Faculdade de Ciências da Nutrição e Alimentação - Porto - Porto - Portugal.
                [10 ] Centro Hospitalar Lisboa Ocidental (CHLO- E.P.E.), Serviço de Reumatologia do Hospital Egas Moniz - Lisboa - Lisboa - Portugal.
                Author notes
                Corresponding author: Cátia Reis. E-mail: reis.catia@ 123456gmail.com
                Article
                10.5935/1984-0063.20180036
                6361301
                30746039
                00ee07db-7cd9-4d4e-8d55-8498ef92c44a

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way.

                History
                : 23 July 2018
                : 27 September 2018
                Categories
                Original Article

                sleep,life style,quality of life,cross-sectional studies,chronic disease,portugal

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