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Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation.
Carlos Orlando Jacobo-Cabral
1 ,
Pilar García-Roca
2 ,
Elba Margarita Romero-Tejeda
3 ,
Herlinda Reyes
2 ,
Mara Medeiros
2
,
4 ,
Gilberto Castañeda-Hernández
1 ,
Iñaki F Trocóniz
5
,
6
Oct 2015
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Abstract
The aims of this study were (i) to develop a population pharmacokinetic (PK) model of tacrolimus in a Mexican renal transplant paediatric population (n = 53) and (ii) to test the influence of different covariates on its PK properties to facilitate dose individualization.