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      Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial.

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          Abstract

          The six-dose regimen of artemether-lumefantrine is effective and is among combination therapies prioritised to replace antimalarials that no longer work in Africa. However, its effectiveness has not been assessed in the field, and could be compromised by poor adherence, incorrect timing of doses, and insufficient intake of fatty foods with every dose. Our aim, therefore, was to assess the effectiveness of artemether-lumefantrine prescribed under routine outpatient conditions, compared with its efficacy when given under supervision to inpatients with acute uncomplicated falciparum malaria.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          April 27 2005
          : 365
          : 9469
          Affiliations
          [1 ] Epicentre, 8 rue Saint-Sabin, 75011 Paris, France. uganda@epicentre.msf.org
          Article
          S0140-6736(05)66416-1
          10.1016/S0140-6736(05)66416-1
          15850630
          9e2a2c5d-804f-43ef-87d3-875e436bee05
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