Efficacy and safety of dihydroartemisinin-piperaquine versus artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ugandan children: a systematic review and meta-analysis of randomized control trials.

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Abstract

The emergence of artemisinin resistance in Southeast Asia and Plasmodium falciparum kelch13 propeller gene mutations in sub-Saharan African pose the greatest threat to global efforts to control malaria. This is a critical concern in Uganda, where artemisinin-based combination therapy (ACT) is the first-line treatment for uncomplicated falciparum. The objective of this study was to compare the efficacy and safety of dihydroartemisinin-piperaquine (DHA-PQ) and artemether-lumefantrine (AL) for the treatment of uncomplicated falciparum malaria in Ugandan children.

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Journal

Journal ID (iso-abbrev): Malar J

Title: Malaria journal

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1475-2875

ISSN (Print): 1475-2875

Publication date (Electronic): Apr 01 2021

Volume: 20

Issue: 1

Affiliations

[1 ] College of Health Sciences, Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia. dawit.getachew@aau.edu.et.

[2 ] Department of Nursing, College of Health Science and Medicine, Dilla University, Dilla, Ethiopia. dawit.getachew@aau.edu.et.

[3 ] College of Health Sciences, Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.

[4 ] Department of Midwifery, College of Health Science, Bule-Hora University, Bule-Hora, Ethiopia.

[5 ] Department of Obstetrics and Gynecology, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

[6 ] Hager Biomedical Research Institute, Asmara, Eritrea.

[7 ] Arsi University, Asella, Ethiopia.

Article

Publisher Item ID: 10.1186/s12936-021-03711-4

DOI: 10.1186/s12936-021-03711-4

PMC ID: 8017896

PubMed ID: 33794897

SO-VID: a7a25831-3d99-4c43-aaeb-748a3cf071d0

History

Keywords: Uncomplicated Plasmodium falciparum,Systematic review and meta-analysis,Randomized controlled trial,Dihydroartemisinin–piperaquine,Children,Artemisinin combination therapies,Artemether–lumefantrine,Uganda

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Keywords: Uncomplicated Plasmodium falciparum, Systematic review and meta-analysis, Randomized controlled trial, Dihydroartemisinin–piperaquine, Children, Artemisinin combination therapies, Artemether–lumefantrine, Uganda

Efficacy and safety of dihydroartemisinin-piperaquine versus artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ugandan children: a systematic review and meta-analysis of randomized control trials.

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