Prevalence of sexual dysfunction in men with multiple sclerosis: a systematic review and meta-analysis.

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Abstract

Symptoms in multiple sclerosis (MS) can lead to different types and ranges of sexual dysfunction in MS patients. Studies in different parts of the world have reported a high range of sexual dysfunction in men with MS. This study aimed to estimate pooled prevalence of sexual dysfunction in men with MS.

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Most cited references 26

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Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement.

Damian Hoy, Peter Brooks, Anthony Woolf … (2012)

In the course of performing systematic reviews on the prevalence of low back and neck pain, we required a tool to assess the risk of study bias. Our objectives were to (1) modify an existing checklist and (2) test the final tool for interrater agreement. The final tool consists of 10 items addressing four domains of bias plus a summary risk of bias assessment. Two researchers tested the interrater agreement of the tool by independently assessing 54 randomly selected studies. Interrater agreement overall and for each individual item was assessed using the proportion of agreement and Kappa statistic. Raters found the tool easy to use, and there was high interrater agreement: overall agreement was 91% and the Kappa statistic was 0.82 (95% confidence interval: 0.76, 0.86). Agreement was almost perfect for the individual items on the tool and moderate for the summary assessment. We have addressed a research gap by modifying and testing a tool to assess risk of study bias. Further research may be useful for assessing the applicability of the tool across different conditions. Copyright © 2012 Elsevier Inc. All rights reserved.

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The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis.

D Tepavcevic, J Kostic, I D Basuroski … (2008)

Sexual dysfunction (SD) is a common but often overlooked symptom in multiple sclerosis (MS). The aim of this study was to estimate the frequency, type, and intensity of SD in our patients with MS and to investigate its influence on all the domains of quality of life. The study population comprised a cohort of 109 patients with MS (McDonald's criteria, 2001). SD was quantified by a Szasz sexual functioning scale. Health-related quality of life was measured by a disease-specific instrument MSQoL-54 (Serbian version). The presence of at least one symptom of SD was found in about 84% of the men and in 85% of the women. The main complaints in women were reduced libido, difficulties in achieving orgasm, and decreased vaginal lubrication; in men, the main complaints were reduced libido, incomplete erections, and premature ejaculation. In women, statistically significant negative correlations between the presence and level of SD and quality of life domains were reached for all subscales (P < 0.01), except for the Pain subscale (P = 0.112). In men, negative correlations were also observed for all domains, but they were statistically significant for physical health, physical role limitations, social function, health distress, sexual function, and sexual function satisfaction (P < 0.01). We found that the presence of all the analyzed types of sexual problems statistically significantly lowered scores on the sexual function and the sexual function satisfaction subscales in both men and women (P < 0.01). The most prominent impact on both domains was observed for the total loss of erection in men and for anorgasmia in women. Our results reveal that frequent occurrence of SD in MS patients prominently affects all aspects of their quality of life.

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Sexual dysfunction ın multiple sclerosis: gender differences.

Derya Kaya, Esra Coskuner Poyraz, Ayhan Bingöl … (2013)

To assess the frequency and nature of sexual dysfunction in multiple sclerosis (MS) patients and to investigate the relationships of SD with clinical, demographic and psychosocial factors by comparing MS patients with and without SD. Eighty-nine patients were included, 45 males and 44 females, aging an average of 37.4 ± 8.6 years (range:21-56). We applied Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) and Arizona Sexual Experiences Scale (ASEX) to all patients. Disability was evaluated with the expanded disability status scale (EDSS). 60.7% (n=54) of patients reported SD according to MSISQ scores. Women exhibited significantly higher MSISQ scores than men (42.6 ± 12.9 and 36.6 ± 13.3, respectively; P=0.034). Women (7.9%) also reported to experience sexual arousal difficulties significantly more than men (1.1%) (P=0.024) according to ASEX. The patients were classified into three MSISQ-19 subscales, Primary, Secondary and Tertiary SD. The most common reported dimension of SD was secondary (32.5%, n=41). In this dimension of SD, patients mostly complained of pain-burning, memory-concentration problems and bowel symptoms. A significant relationship was found between Secondary SD and both EDSS score and disease duration (r=0.34 p=0.001 and r=0.21 p=0.042, respectively). Tertiary SD was also associated with EDSS score (r=0.23 p=0.03). Sexual Dysfunction, a frequent problem for MS patients, is associated with gender. Women reported more SD than men. Secondary SD symptoms were the most common complaints for both men and women. Nonetheless women had more secondary SD symptoms than men. The emotional dimension of SD is related with disability. Copyright © 2012 Elsevier B.V. All rights reserved.

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Journal

Journal ID (iso-abbrev): Syst Rev

Title: Systematic reviews

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 2046-4053

ISSN (Print): 2046-4053

Publication date (Electronic): January 06 2021

Volume: 10

Issue: 1

Affiliations

[1 ] Department of Biostatistics and Epidemiology, Social Determinants of Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

[2 ] Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran.

[3 ] Department of Brain and Cognitive Sciences, Royan Institute for Stem Cell Biology and Technology, ACCR, Royan, Iran.

[4 ] Dezful University of Medical Sciences, Dezful, Iran. raana.kousari@gmail.com.

Article

Publisher Item ID: 10.1186/s13643-020-01560-x

DOI: 10.1186/s13643-020-01560-x

PMC ID: 7789133

PubMed ID: 33407874

SO-VID: 49b60b4e-e0d6-4705-838c-a17aeed7a7fe

History

Keywords: Men,Systematic review,Sexual dysfunction,Prevalence,Multiple sclerosis

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Keywords: Men, Systematic review, Sexual dysfunction, Prevalence, Multiple sclerosis

Prevalence of sexual dysfunction in men with multiple sclerosis: a systematic review and meta-analysis.

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REPO4EU WP2 Systematic Reviews

Most cited references 26

Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement.

The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis.

Sexual dysfunction ın multiple sclerosis: gender differences.

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