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Abstract

The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors. CB2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas.

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PubMed ID:: 16224028

DOI:: 10.1126/science.1115740

ScienceOpen disciplines: Chemistry

Keywords: Animals,Arachidonic Acids,pharmacology,Blotting, Western,Brain Stem,metabolism,Cannabinoid Receptor Modulators,Cannabinoids,Cerebellum,Cerebral Cortex,Endocannabinoids,Ferrets,Immunohistochemistry,Mice,Polyunsaturated Alkamides,RNA, Messenger,analysis,Rats,Receptor, Cannabinoid, CB2,agonists,antagonists & inhibitors,Reverse Transcriptase Polymerase Chain Reaction,Vomiting,prevention & control

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ScienceOpen disciplines: Chemistry

Keywords: Animals, Arachidonic Acids, pharmacology, Blotting, Western, Brain Stem, metabolism, Cannabinoid Receptor Modulators, Cannabinoids, Cerebellum, Cerebral Cortex, Endocannabinoids, Ferrets, Immunohistochemistry, Mice, Polyunsaturated Alkamides, RNA, Messenger, analysis, Rats, Receptor, Cannabinoid, CB2, agonists, antagonists & inhibitors, Reverse Transcriptase Polymerase Chain Reaction, Vomiting, prevention & control

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