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      miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice.

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          Abstract

          Recently, there has been significant interest in the therapeutic administration of miRNA mimics and inhibitors to treat cardiovascular disease. In particular, miR-27b has emerged as a regulatory hub in cholesterol and lipid metabolism and potential therapeutic target for treating atherosclerosis. Despite this, the impact of miR-27b on lipid levels in vivo remains to be determined. As such, here we set out to further characterize the role of miR-27b in regulating cholesterol metabolism in vitro and to determine the effect of miR-27b overexpression and inhibition on circulating and hepatic lipids in mice.

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          Author and article information

          Journal
          Atherosclerosis
          Atherosclerosis
          Elsevier BV
          1879-1484
          0021-9150
          Dec 2015
          : 243
          : 2
          Affiliations
          [1 ] Section of Comparative Medicine, Department of Pathology, Program in Integrative Cell Signaling and Neurobiology of Metabolism and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA.
          [2 ] Edward A. Doisy Department of Biochemistry and Molecular Biology, Center for Cardiovascular Research, Saint Louis University School of Medicine, Saint Louis, MO, USA.
          [3 ] Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
          [4 ] Section of Comparative Medicine, Department of Pathology, Program in Integrative Cell Signaling and Neurobiology of Metabolism and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA. Electronic address: carlos.fernandez@yale.edu.
          Article
          S0021-9150(15)30142-8 NIHMS735530
          10.1016/j.atherosclerosis.2015.09.033
          4975922
          26520906
          f215333e-eebf-4f79-9e33-188f6db217ef
          History

          Lipid homeostasis,miR-27b,miRNAs,ABCA1,Atherosclerosis,LDLR
          Lipid homeostasis, miR-27b, miRNAs, ABCA1, Atherosclerosis, LDLR

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