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      A qualitative systematic review of factors influencing parents' vaccination decision-making in the United Kingdom.

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          Abstract

          High uptake of vaccinations is crucial for disease prevention. Although overall uptake of childhood immunisations is high in the United Kingdom (UK), pockets of lower uptake remain. Novel systematic methods have not been employed when reviewing the qualitative literature examining parents' vaccination decisions.

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          Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

          David Moher, Alessandro Liberati, Jennifer Tetzlaff … (2009)
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            Vaccine hesitancy: Definition, scope and determinants.

            Noni MacDonald (2015)
            The SAGE Working Group on Vaccine Hesitancy concluded that vaccine hesitancy refers to delay in acceptance or refusal of vaccination despite availability of vaccination services. Vaccine hesitancy is complex and context specific, varying across time, place and vaccines. It is influenced by factors such as complacency, convenience and confidence. The Working Group retained the term 'vaccine' rather than 'vaccination' hesitancy, although the latter more correctly implies the broader range of immunization concerns, as vaccine hesitancy is the more commonly used term. While high levels of hesitancy lead to low vaccine demand, low levels of hesitancy do not necessarily mean high vaccine demand. The Vaccine Hesitancy Determinants Matrix displays the factors influencing the behavioral decision to accept, delay or reject some or all vaccines under three categories: contextual, individual and group, and vaccine/vaccination-specific influences.
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              Methods for the thematic synthesis of qualitative research in systematic reviews

              James Thomas, Angela Harden (2008)
              Background There is a growing recognition of the value of synthesising qualitative research in the evidence base in order to facilitate effective and appropriate health care. In response to this, methods for undertaking these syntheses are currently being developed. Thematic analysis is a method that is often used to analyse data in primary qualitative research. This paper reports on the use of this type of analysis in systematic reviews to bring together and integrate the findings of multiple qualitative studies. Methods We describe thematic synthesis, outline several steps for its conduct and illustrate the process and outcome of this approach using a completed review of health promotion research. Thematic synthesis has three stages: the coding of text 'line-by-line'; the development of 'descriptive themes'; and the generation of 'analytical themes'. While the development of descriptive themes remains 'close' to the primary studies, the analytical themes represent a stage of interpretation whereby the reviewers 'go beyond' the primary studies and generate new interpretive constructs, explanations or hypotheses. The use of computer software can facilitate this method of synthesis; detailed guidance is given on how this can be achieved. Results We used thematic synthesis to combine the studies of children's views and identified key themes to explore in the intervention studies. Most interventions were based in school and often combined learning about health benefits with 'hands-on' experience. The studies of children's views suggested that fruit and vegetables should be treated in different ways, and that messages should not focus on health warnings. Interventions that were in line with these suggestions tended to be more effective. Thematic synthesis enabled us to stay 'close' to the results of the primary studies, synthesising them in a transparent way, and facilitating the explicit production of new concepts and hypotheses. Conclusion We compare thematic synthesis to other methods for the synthesis of qualitative research, discussing issues of context and rigour. Thematic synthesis is presented as a tried and tested method that preserves an explicit and transparent link between conclusions and the text of primary studies; as such it preserves principles that have traditionally been important to systematic reviewing.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): SSM Popul Health
                Title: SSM - population health
                Publisher: Elsevier BV
                ISSN: 2352-8273
                ISSN (Print): 2352-8273
                Publication date (Electronic): Dec 2016
                Volume: 2
                Affiliations
                [1 ] Health Behaviour Research Centre, UCL, Gower Street, London WC1E 6BT, United Kingdom.
                [2 ] Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, United Kingdom.
                [3 ] Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom.
                Article
                Publisher Item ID: S2352-8273(16)30047-7
                DOI: 10.1016/j.ssmph.2016.07.005
                PMC ID: 5165048
                PubMed ID: 28018959
                SO-VID: bfe94aac-72a8-43c1-b4b6-f269753902fc
                History

                Keywords: Parents,Patient Acceptance of Health Care,Thematic synthesis,Vaccination
                Data availability:
                Keywords: Parents, Patient Acceptance of Health Care, Thematic synthesis, Vaccination

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