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      Breast cancer cell lines: friend or foe?

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          Abstract

          The majority of breast cancer research is conducted using established breast cancer cell lines as in vitro models. An alternative is to use cultures established from primary breast tumours. Here, we discuss the pros and cons of using both of these models in translational breast cancer research.

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          A human cell line from a pleural effusion derived from a breast carcinoma.

          H D Soule, J. Vázquez, A. Long … (1973)
          Article 0 comments Cited 262 times – based on 0 reviews     Review now
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            Breast tumor cell lines from pleural effusions.

            R. Cailleau, R. Young, M. Olive … (1974)
            Article 0 comments Cited 180 times – based on 0 reviews     Review now
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              Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization.

              R Cailleau, M Olivé, Q V Cruciger (1978)
              Nineteen human breast carcinoma cell lines have been established as continuous cultures during the past 6 years in our laboratory. This preliminary report is designed to list the lines by their designated code numbers (MDA-MB) and present a brief summary of their morphological, cytogenetic and biochemical characteristics. Sixteen of our lines were obtained from pleural effusions, two from brain metastases, and one from pericardial fluid. All lines have been shown to be distinct entities and are uncontaminated by HeLa cells or each other. A lq marker chromosome is present in all but one of the lines examined.
              Article 0 comments Cited 172 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Breast Cancer Res
                Title: Breast Cancer Research
                Publisher: BioMed Central (London )
                ISSN (Print): 1465-5411
                ISSN (Electronic): 1465-542X
                Publication date (Print): 2003
                Publication date (Electronic): 3 February 2003
                Volume: 5
                Issue: 2
                Pages: 89-95
                Affiliations
                [1 ]Molecular Medicine Unit, University of Leeds, Leeds, UK
                [2 ]Breast Unit, St James's University Hospital, Leeds, UK
                [3 ]Academic Unit of Pathology, University of Leeds, Leeds, UK
                Article
                Publisher ID: bcr577
                PMC ID: 154155
                PubMed ID: 12631387
                SO-VID: 73ef3d9e-4ad6-4c4e-b875-ba4d9f1b30a1
                Copyright © Copyright © 2003 BioMed Central Ltd
                History
                Date received : 8 November 2002
                Date revision received : 10 January 2003
                Date accepted : 20 January 2003
                Categories
                Subject: Review

                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: mammary gland,cell culture,in vitro models
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: mammary gland, cell culture, in vitro models

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