Induced Pluripotent Stem Cells Meet Genome Editing.

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Abstract

It is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how two such experiments-the generation of human induced pluripotent stem cells (iPSCs) and the development of CRISPR/Cas9 technology-have fundamentally reshaped our approach to biomedical research, stem cell biology, and human genetics. We will also highlight the previous knowledge that iPSC and CRISPR/Cas9 technologies were built on as this groundwork demonstrated the need for solutions and the benefits that these technologies provided and set the stage for their success.

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Journal

Journal ID (iso-abbrev): Cell Stem Cell

Title: Cell stem cell

ISSN (Electronic): 1875-9777

ISSN (Print): 1875-9777

Publication date (Electronic): May 5 2016

Volume: 18

Issue: 5

Affiliations

[1 ] Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: hockemeyer@berkeley.edu.

[2 ] The Whitehead Institute for Biomedical Research and Department of Biology, MIT, Cambridge, MA 02142, USA.

Article

Publisher Item ID: S1934-5909(16)30056-X Mid ID: NIHMS783629

DOI: 10.1016/j.stem.2016.04.013

PMC ID: 4871596

PubMed ID: 27152442

SO-VID: 58d87353-3cd1-4942-8d55-635bb345c034

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