Establishment of induced pluripotent stem cells from a patient with 16p13.11 duplication and VPS13B deletion.

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Abstract

VPS13B deletion and 16p13.11 duplication are related to mental disorders, such as schizophrenia. However, how these variants affect human neurons and contribute to the development of mental disorders is yet to be elucidated. In this study, we generated induced pluripotent stem cells (iPSCs) from a patient with 16p13.11 duplication and VPS13B deletion. The iPSCs indicated pluripotency marker expression and the differentiation capacity into three germ layers in vitro. Therefore, these iPSC lines will be useful tools to further understand the pathophysiology of mental disorders.

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Journal

Journal ID (iso-abbrev): Stem Cell Res

Title: Stem cell research

Publisher: Elsevier BV

ISSN (Electronic): 1876-7753

ISSN (Print): 1873-5061

Publication date (Electronic): Oct 2022

Volume: 64

Affiliations

[1 ] Pathophysiology of Psychiatric Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Hospital Pharmacy, Nagoya University Hospital, Nagoya, Japan.

[2 ] Pathophysiology of Psychiatric Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan. Electronic address: ariokay@med.nagoya-u.ac.jp.

[3 ] Pathophysiology of Psychiatric Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan; Medical Genomics Center, Nagoya University Hospital, Nagoya, Japan.

[4 ] Pathophysiology of Psychiatric Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan; Brain and Mind Research Center, Nagoya University, Nagoya, Japan.

[5 ] Pathophysiology of Psychiatric Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan; Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, Japan.

Article

Publisher Item ID: S1873-5061(22)00233-1

DOI: 10.1016/j.scr.2022.102884

PubMed ID: 35944312

SO-VID: dda29f66-6849-4e5c-91fe-c48d8223364e

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