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Therapeutic effect of lenalidomide in a novel xenograft mouse model of human blastic NK cell lymphoma/blastic plasmacytoid dendritic cell neoplasm.
Alice Agliano
1 ,
Ines Martin-Padura ,
Paola Marighetti ,
Giuliana Gregato ,
Angelica Calleri ,
Celia Prior ,
Miriam Redrado ,
Alfonso Calvo ,
Francesco Bertolini
Oct 01 2011
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Abstract
Blastic natural killer (NK) cell lymphoma/blastic plasmacytoid dendritic cell neoplasm (BNKL) is a rare and aggressive neoplasia characterized by infiltration of blast CD4(+)/CD56(+) cells in the skin, the bone marrow, and peripheral blood. Currently, more efforts are required to better define molecular and biological mechanisms associated with this pathology. To the best of our knowledge, no mouse model recapitulated human BNKL so far.