lncRNAs as Potential Targets in Small Cell Lung Cancer: MYC -dependent Regulation.

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Abstract

Small Cell Lung Cancer (SCLC) is a highly aggressive malignancy. MYC family oncogenes are amplified and overexpressed in 20% of SCLCs, showing that MYC oncogenes and MYC regulated genes are strong candidates as therapeutic targets for SCLC. c-MYC plays a fundamental role in cancer stem cell properties and malignant transformation. Several targets have been identified by the activation/repression of MYC. Deregulated expression levels of lncRNAs have also been observed in many cancers.

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Author and article information

Journal

Journal ID (iso-abbrev): Anticancer Agents Med Chem

Title: Anti-cancer agents in medicinal chemistry

Publisher: Bentham Science Publishers Ltd.

ISSN (Electronic): 1875-5992

ISSN (Print): 1871-5206

Publication date (Electronic): 2020

Volume: 20

Issue: 17

Affiliations

[1 ] Department of Medical Genetics, Faculty of Medicine, Pamukkale University, Denizli, Turkey

[2 ] Department of Cancer Molecular Biology, Institute of Medical Sciences, Pamukkale University, Denizli, Turkey

Article

Publisher Item ID: ACAMC-EPUB-108377

DOI: 10.2174/1871520620666200721130700

PubMed ID: 32698750

SO-VID: 8a85e16f-3eb6-4c9e-b703-b939094ab57d

History

Keywords: MYC ,SCLC,inhibition,lentiviral vector,lncRNA,overexpression

Data availability:

Keywords: MYC , SCLC, inhibition, lentiviral vector, lncRNA, overexpression

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