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Effectiveness of digoxin in reducing one-year mortality in chronic heart failure in the Digitalis Investigation Group trial.

Author(s): Ali Ahmed, Finn Waagstein, Bertram Pitt, Michel White, Faiez Zannad, James B. Young, Shahbudin Rahimtoola

Publication date: 2009-01-01

Journal: The American Journal of Cardiology

Keywords: Aged, Canada, epidemiology, Cardiotonic Agents, administration & dosage, Cause of Death, trends, Chronic Disease, Digoxin, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Heart Failure, drug therapy, mortality, Humans, Male, Middle Aged, Survival Rate, Time Factors, Treatment Outcome, United States

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Abstract

Post hoc analyses of the Digitalis Investigation Group (DIG) trial indicate that digoxin at low (0.5 to 0.9 ng/ml) serum digoxin concentration (SDC) reduces mortality, which is eliminated at higher (>or=1 ng/ml) SDC, and that low-dose digoxin (

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PubMed ID:: 19101235

PMC ID:: 2900803

DOI:: 10.1016/j.amjcard.2008.06.068

ScienceOpen disciplines: Chemistry

Keywords: Aged,Canada,epidemiology,Cardiotonic Agents,administration & dosage,Cause of Death,trends,Chronic Disease,Digoxin,Dose-Response Relationship, Drug,Female,Follow-Up Studies,Heart Failure,drug therapy,mortality,Humans,Male,Middle Aged,Survival Rate,Time Factors,Treatment Outcome,United States

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ScienceOpen disciplines: Chemistry

Effectiveness of digoxin in reducing one-year mortality in chronic heart failure in the Digitalis Investigation Group trial.

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