Air pollution has been related to incidence of type 2 diabetes (T2D). We assessed the joint association of various air pollutants with the risk of T2D and examined potential modification by obesity status and genetic susceptibility on the relationship.
A total of 449,006 participants from UK Biobank free of T2D at baseline were included. Of all the study population, 90.9% were white and 45.7% were male. The participants had a mean age of 56.6 (SD 8.1) years old and a mean body mass index (BMI) of 27.4 (SD 4.8) kg/m 2. Ambient air pollutants, including particulate matter (PM) with diameters ≤2.5 μm (PM 2.5), between 2.5 μm and 10 μm (PM 2.5–10), nitrogen dioxide (NO 2), and nitric oxide (NO) were measured. An air pollution score was created to assess the joint exposure to the 4 air pollutants. During a median of 11 years follow-up, we documented 18,239 incident T2D cases. The air pollution score was significantly associated with a higher risk of T2D. Compared to the lowest quintile of air pollution score, the hazard ratio (HR) (95% confidence interval [CI]) for T2D was 1.05 (0.99 to 1.10, p = 0.11), 1.06 (1.00 to 1.11, p = 0.051), 1.09 (1.03 to 1.15, p = 0.002), and 1.12 (1.06 to 1.19, p < 0.001) for the second to fifth quintile, respectively, after adjustment for sociodemographic characteristics, lifestyle factors, genetic factors, and other covariates. In addition, we found a significant interaction between the air pollution score and obesity status on the risk of T2D ( p-interaction < 0.001). The observed association was more pronounced among overweight and obese participants than in the normal-weight people. Genetic risk score (GRS) for T2D or obesity did not modify the relationship between air pollution and risk of T2D. Key study limitations include unavailable data on other potential T2D-related air pollutants and single-time measurement on air pollutants.
We found that various air pollutants PM 2.5, PM 2.5–10, NO 2, and NO, individually or jointly, were associated with an increased risk of T2D in the population. The stratified analyses indicate that such associations were more strongly associated with T2D risk among those with higher adiposity.
Xiang Li and co-workers study the potential influence of obesity on associations between air pollutants and incidence of type 2 diabetes.
Recent evidence has linked ambient air pollution with type 2 diabetes (T2D). However, most of them were mainly focused on 1 or 2 air pollutants separately. In addition, it has been reported that the association between air pollution and T2D was augmented among people with increased adiposity.
Individuals are usually exposed to various air pollutants simultaneously; and the importance of assessing multi-air pollutant exposures as a whole has been increasingly recognized.
Thus, in this study, we aimed to analyze the association between the air pollution score that incorporates various air pollutants with the risk of T2D. We also particularly examined the potential modification by obesity.
We built an air pollution score, incorporating PM 2.5, PM 2.5–10, nitrogen dioxide (NO 2), and nitric oxide (NO), and analyzed its association with the risk of T2D among 449,006 participants from UK Biobank. Air pollutants were measured in 2010. During a median follow-up time of 11 years, 18,239 T2D cases were documented.
We found that long-term exposure to various air pollutants, individually or jointly, was associated with an increased risk of T2D. Moreover, such association was more pronounced among people with increased adiposity.
Our findings highlight the importance of comprehensively assessing various air pollutants as a whole in the prevention of T2D.
Given the adverse impact of air pollution on T2D, attention should be paid to reducing and mitigating air pollution.
Our results also emphasize the merit of obesity management.