The differences of the impact of a lipid and protein corona on the colloidal stability, toxicity, and degradation behavior of iron oxide nanoparticles.

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Abstract

In this study, the influence of a serum albumin (SA) and human plasma (HP) derived protein- and lipid molecule corona on the toxicity and biodegradability of different iron oxide nanoparticles (IONP) was investigated.

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Journal

Journal ID (iso-abbrev): Nanoscale

Title: Nanoscale

Publisher: Royal Society of Chemistry (RSC)

ISSN (Electronic): 2040-3372

ISSN (Print): 2040-3364

Publication date (Electronic): May 27 2021

Volume: 13

Issue: 20

Affiliations

[1 ] Pharmaceutical Technology and Biopharmacy, Friedrich-Schiller-University Jena, Lessingstraße 8, 07743 Jena, Germany.

[2 ] Department of Pharmaceutical and Medical Chemistry, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743 Jena, Germany.

[3 ] micromod Partikeltechnologie GmbH, Friedrich-Barnewitz-Straße 4, 18119 Rostock, Germany.

[4 ] chemicell GmbH, Eresburgstraße 22-23, 12103 Berlin, Germany.

[5 ] Otto Schott Institute of Materials Research (OSIM), Friedrich-Schiller-University Jena, Löbdergraben 32, 07743 Jena, Germany.

[6 ] Department of Pharmaceutical and Medical Chemistry, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743 Jena, Germany and Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Mitterweg 24, 6020 Innsbruck, Austria.

[7 ] Department of Chemistry and Pharmacy, Friedrich-Alexander-University Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany. dagmar.fischer@fau.de.

Article

DOI: 10.1039/d0nr09053k

PubMed ID: 34002735

SO-VID: cf3c4881-e273-4943-bb43-d6309d36561b

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