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Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.
Slaheddine Marrakchi
1 ,
Philippe Guigue ,
Blair R Renshaw ,
Anne Puel ,
Xue-Yuan Pei ,
Sylvie Fraitag ,
Jihen Zribi ,
Elodie Bal ,
Céline Cluzeau ,
Maya Chrabieh ,
Jennifer E Towne ,
Jason Douangpanya ,
Christian Pons ,
Sourour Mansour ,
Valérie Serre ,
Hafedh Makni ,
Nadia Mahfoudh ,
Faiza Fakhfakh ,
Christine Bodemer ,
Josué Feingold ,
Smail Hadj-Rabia ,
Michel Favre ,
Emmanuelle Genin ,
Mourad Sahbatou ,
Arnold Munnich ,
Jean-Laurent Casanova ,
John E Sims ,
Hamida Turki ,
Hervé Bachelez ,
Asma Smahi
Aug 18 2011
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Abstract
Generalized pustular psoriasis is a life-threatening disease of unknown cause. It is characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein, which may be associated with plaque-type psoriasis.