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      Evaluación antiinflamatoria del flavonoide 2"- o- ramnosil 4"- o- metil vitexina en ratas

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          Abstract

          Con el objetivo de evaluar el efecto antiinflamatorio del flavonoide 2" -o- ramnosil 4" - o- metil vitexina, aislado de las hojas de Piper ossanum, se utilizó un modelo de inflamación crónica en ratas. La dosis ensayada fue 0,2 mg/kg y la variable fue el porcentaje de inhibición de la inflamación. Se encontró un significativo efecto antiinflamatorio de la droga evaluada con respecto al grupo control. No se encontraron diferencias entre el flavonoide y el piroxican (control positivo utilizado en el estudio). El nivel de significación se fijó en una p menor o igual a 0,05.

          Translated abstract

          In order to evaluate the antiinflammatory effect of flavanoid 2" -o- ramnosil 4" -o- methyl vitexin isolated from the leaves of Piper ossanum, a model of chronic inflammation was used in rats. The tested dose was 0.2 mg/Kg and the variable was the inflammation's percentage of inhibition. A significant antiinflammatory effect of the evaluated drug was found compared with the control group. No differences between the flavonoid and piroxican (positive control used in the study) were observed. The significance level was fixed at a p smaller than or equal to 0.05.

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          Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.).

          Separation and isolation of the genuine faradiol esters (1, 2) from flower heads of Marigold (Calendula (officinalis L., Asteraceae) could be achieved by means of repeated column chromatography (CC) and HPLC for the first time. Structure elucidation of faradiol-3-myristic acid ester 1, faradiol-3-palmitic acid ester 2 and psi-taraxasterol 3 has been also performed, without any previous degradation by means of MS, 1H-NMR, 13C-NMR and 2D-NMR experiments. The anti-oedematous activities of these three compounds were tested by means of inhibition of Croton oil-induced oedema of the mouse ear. Both faradiol esters showed nearly the same dose dependent anti-oedematous activity and no significant synergism appeared with their mixture. The free monol, psi-taraxasterol, had a slightly lower effect. Furthermore, faradiol was more active than its esters and than psi-taraxasterol and showed the same effect as an equimolar dose of indomethacin.
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            Plantas medicinales, aromáticas y venenosas en Cuba

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              Contribución al estudio de algunas especies de la familia Piperaceae

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                Author and article information

                Journal
                pla
                Revista Cubana de Plantas Medicinales
                Rev Cubana Plant Med
                ECIMED (Ciudad de la Habana, , Cuba )
                1028-4796
                April 2004
                : 9
                : 1
                Affiliations
                [01] La Habana orgnameHospital Militar Central Dr. Luis Díaz Soto orgdiv1Laboratorio de Medicina Herbaria. Cuba ismmds@ 123456infomed.sld.cu
                Article
                S1028-47962004000100008 S1028-4796(04)00900108
                6fee297e-76b4-4dcc-87fe-728b59b46907

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 05 January 2004
                : 21 January 2004
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 8, Pages: 0
                Product

                SciELO Cuba

                Categories
                ARTÍCULOS ORIGINALES

                extractos vegetales,Plantas medicinales,modelos animales de enfermedad,PLANTS, MEDICINAL,ratas wistar,PLANT EXTRACTS,RATS, WISTAR,DISEASE MODELS, ANIMAL

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