Maud Gratuze:
ORCID: https://orcid.org/0000-0002-1552-8815
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: ValidationRole:
VisualizationRole: Writing - original draftRole: Writing - review & editing
Yun Chen:
ORCID: https://orcid.org/0000-0003-0547-9463
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ValidationRole: Writing - original draft
Samira Parhizkar:
ORCID: https://orcid.org/0000-0001-5807-190X
Role: InvestigationRole: ValidationRole: Writing - review & editing
Nimansha Jain:
ORCID: https://orcid.org/0000-0001-5360-5466
Role: Data curationRole: InvestigationRole: SoftwareRole: ValidationRole: VisualizationRole:
Writing - review & editing
Michael R. Strickland:
ORCID: https://orcid.org/0000-0002-3899-5651
Role: InvestigationRole: ResourcesRole: Writing - review & editing
Javier Remolina Serrano:
ORCID: https://orcid.org/0000-0002-5937-0212
Role: Investigation
Marco Colonna:
ORCID: https://orcid.org/0000-0001-5222-4987
Role: Methodology
Jason D. Ulrich:
ORCID: https://orcid.org/0000-0002-4743-926X
Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing - original
draftRole: Writing - review & editing
David M. Holtzman:
ORCID: https://orcid.org/0000-0002-3400-0856
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole:
Writing - original draftRole: Writing - review & editing
Journal ID (nlm-ta): J Exp Med
Journal ID (iso-abbrev): J Exp Med
Journal ID (publisher-id): jem
Title:
The Journal of Experimental Medicine
Publisher:
Rockefeller University Press
ISSN
(Print):
0022-1007
ISSN
(Electronic):
1540-9538
Publication date Collection: 02
August
2021
Publication date
(Electronic):
08
June
2021
Volume: 218
Issue: 8
Electronic Location Identifier: e20210542
Affiliations
[1
]
Department of Neurology, Washington University School of Medicine, St. Louis, MO
[2
]
Department of Pathology and Immunology, Washington University School of Medicine,
St. Louis, MO
[3
]
Hope Center for Neurological Disorders, Washington University School of Medicine,
St. Louis, MO
[4
]
Knight Alzheimer’s Disease Research Center, Washington University School of Medicine,
St. Louis, MO
Author notes
Disclosures: M. Colonna reported "other" from Vigil Neuroscience, and grants from
Ono and Pfizer outside the submitted work; in addition, M. Colonna had a patent to
TREM2 pending. J.D. Ulrich reported a patent to anti-TREM2 agonist antibodies pending.
D.M. Holtzman reported grants from NIH, JPB Foundation, Charles and Helen Schwab Foundation,
and Edward N. and Della L. Thome Memorial Foundation during the conduct of the study;
"other" from C2N Diagnostics; and personal fees from Denali, Genentech, Merck, Cajal
Neurosciences, and Takeda outside the submitted work; in addition, D.M. Holtzman had
a patent to anti-tau antibodies licensed and a provisional patent on anti-TREM2 antibodies
pending. No other disclosures were reported.
Author information
Article
Publisher ID:
jem.20210542
DOI: 10.1084/jem.20210542
PMC ID: 8190588
PubMed ID: 34100905
SO-VID: 9f335394-90cd-4853-9403-92008fb197c3
Copyright © © 2021 Gratuze et al.
License:
This article is distributed under the terms of an Attribution–Noncommercial–Share
Alike–No Mirror Sites license for the first six months after the publication date
(see
http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share
Alike 4.0 International license, as described at
https://creativecommons.org/licenses/by-nc-sa/4.0/).
Funded by: BrightFocus Foundation, DOI http://dx.doi.org/10.13039/100006312;
Award ID: A2020257F
Funded by: National Institutes of Health, DOI http://dx.doi.org/10.13039/100000002;
Award ID: AG047644
Award ID: UL1 TR000448
Funded by: JPB Foundation, DOI http://dx.doi.org/10.13039/100007457;
Funded by: Charles and Helen Schwab Foundation;
Funded by: Edward N. and Della L. Thome Memorial Foundation, DOI http://dx.doi.org/10.13039/100008097;
Funded by: NIH Office of the Director, DOI http://dx.doi.org/10.13039/100000002;
Award ID: OD021629
Funded by: Washington University School of Medicine, DOI http://dx.doi.org/10.13039/100011912;
Funded by: Children’s Discovery Institute of Washington University;
Funded by: St. Louis Children’s Hospital;
Award ID: CDI-CORE-2015-505
Award ID: CDI-CORE-2019-813
Funded by: Foundation for Barnes-Jewish Hospital, DOI http://dx.doi.org/10.13039/100007338;
Award ID: 3770
Award ID: 4642
Funded by: National Cancer Institute, DOI http://dx.doi.org/10.13039/100000054;
Award ID: P30 CA91842
Funded by: National Center for Research Resources, DOI http://dx.doi.org/10.13039/100000097;