γ-aminobutyric acid stimulates β-cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel γ-aminobutyric acid type A receptor positive allosteric modulator.

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Abstract

To examine the mechanism of action of γ-aminobutyric acid (GABA) on β-cell proliferation and investigate if co-treatment with Ly49, a novel GABA type A receptor positive allosteric modulator (GABAA -R PAM), amplifies this effect.

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Author and article information

Journal

Journal ID (iso-abbrev): Diabetes Obes Metab

Title: Diabetes, obesity & metabolism

Publisher: Wiley

ISSN (Electronic): 1463-1326

ISSN (Print): 1462-8902

Publication date (Electronic): November 2020

Volume: 22

Issue: 11

Affiliations

[1 ] Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

[2 ] Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

[3 ] Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.

[4 ] Diabetes and Complications Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.

[5 ] Institute for Metabolic Disease, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai, China.

Article

DOI: 10.1111/dom.14118

PubMed ID: 32558194

SO-VID: f642c5ed-d217-4888-8ae8-3bfc4f23eb5c

History

Keywords: β-cell, GABA, GABAA receptor, mTORC1, p70S6K, proliferation

Data availability:

Keywords: β-cell, GABA, GABAA receptor, mTORC1, p70S6K, proliferation

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