Cambios respiratorios y hemodinámicos durante una maniobra de reclutamiento pulmonar mediante incrementos y decrementos progresivos de PEEP

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Objetivo: Estudiar los cambios respiratorios y hemodinámicos durante una maniobra de reclutamiento pulmonar (MRP) mediante incrementos y decrementos progresivos de PEEP. Diseño y ámbito: Estudio retrospectivo en una UCI de 17 camas. Pacientes: Un total de 21 pacientes con insuficiencia respiratoria aguda e infiltrados pulmonares bilaterales. Intervención: MRP consistente en incrementos progresivos de PEEP (4cmH2O cada 3 minutos), con presión de ventilación fija, hasta alcanzar un valor máximo de 36cmH2O de PEEP (rama ascendente), seguida de decrementos progresivos (2cmH2O cada 3 minutos) hasta establecer la PEEP de apertura en el valor asociado a la máxima distensibilidad del sistema respiratorio (Dsr) (rama descendente). La monitorización hemodinámica se realizó de forma continua con una sonda ecodoppler esofágica. Resultados: La Dsr disminuyó gradualmente en la rama ascendente de la MRP y aumentó de forma progresiva superando el valor inicial al establecer la PEEP de apertura en la rama descendente, reduciéndose la presión de ventilación y aumentando la relación SpO2/FiO2. Los cambios hemodinámicos consistieron fundamentalmente en una disminución del gasto cardiaco y de la precarga del ventrículo izquierdo, junto con un aumento de la frecuencia y de la contractilidad cardiaca. A niveles equiparables de PEEP y presión media en vía aérea, estos cambios fueron más intensos durante la rama descendente. Conclusiones: 1) La realización de la MRP incrementó la Dsr mejorando la oxigenación y disminuyendo la presión de ventilación; 2) la principal consecuencia hemodinámica fue la disminución del gasto cardiaco y de la precarga ventricular izquierda; 3) la afectación hemodinámica desigual en ambas ramas, a niveles equiparables de PEEP y presión media en vía aérea, puso de manifiesto que, junto a la presión intratorácica, otros factores como la Dsr y la hipercapnia pudieron influir en las consecuencias hemodinámicas en este tipo de MRP.

Related collections

Most cited references 80

Record: found
Abstract: found
Article: not found

Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.

M. B. P. Amato, C Barbas, D M Medeiros … (1998)

In patients with the acute respiratory distress syndrome, massive alveolar collapse and cyclic lung reopening and overdistention during mechanical ventilation may perpetuate alveolar injury. We determined whether a ventilatory strategy designed to minimize such lung injuries could reduce not only pulmonary complications but also mortality at 28 days in patients with the acute respiratory distress syndrome. We randomly assigned 53 patients with early acute respiratory distress syndrome (including 28 described previously), all of whom were receiving identical hemodynamic and general support, to conventional or protective mechanical ventilation. Conventional ventilation was based on the strategy of maintaining the lowest positive end-expiratory pressure (PEEP) for acceptable oxygenation, with a tidal volume of 12 ml per kilogram of body weight and normal arterial carbon dioxide levels (35 to 38 mm Hg). Protective ventilation involved end-expiratory pressures above the lower inflection point on the static pressure-volume curve, a tidal volume of less than 6 ml per kilogram, driving pressures of less than 20 cm of water above the PEEP value, permissive hypercapnia, and preferential use of pressure-limited ventilatory modes. After 28 days, 11 of 29 patients (38 percent) in the protective-ventilation group had died, as compared with 17 of 24 (71 percent) in the conventional-ventilation group (P<0.001). The rates of weaning from mechanical ventilation were 66 percent in the protective-ventilation group and 29 percent in the conventional-ventilation group (P=0.005): the rates of clinical barotrauma were 7 percent and 42 percent, respectively (P=0.02), despite the use of higher PEEP and mean airway pressures in the protective-ventilation group. The difference in survival to hospital discharge was not significant; 13 of 29 patients (45 percent) in the protective-ventilation group died in the hospital, as compared with 17 of 24 in the conventional-ventilation group (71 percent, P=0.37). As compared with conventional ventilation, the protective strategy was associated with improved survival at 28 days, a higher rate of weaning from mechanical ventilation, and a lower rate of barotrauma in patients with the acute respiratory distress syndrome. Protective ventilation was not associated with a higher rate of survival to hospital discharge.

0 comments Cited 551 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome.

Pier Paolo Terragni, Giulio Rosboch, Andrea Tealdi … (2007)

Tidal volume and plateau pressure limitation decreases mortality in acute respiratory distress syndrome. Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may be hyperinflated by tidal inflation. We hypothesized that despite tidal volume and plateau pressure limitation, patients with a larger nonaerated compartment are exposed to tidal hyperinflation of the normally aerated compartment. Pulmonary computed tomography at end-expiration and end-inspiration was obtained in 30 patients ventilated with a low tidal volume (6 ml/kg predicted body weight). Cluster analysis identified 20 patients in whom tidal inflation occurred largely in the normally aerated compartment (69.9 +/- 6.9%; "more protected"), and 10 patients in whom tidal inflation occurred largely within the hyperinflated compartments (63.0 +/- 12.7%; "less protected"). The nonaerated compartment was smaller and the normally aerated compartment was larger in the more protected patients than in the less protected patients (p = 0.01). Pulmonary cytokines were lower in the more protected patients than in the less protected patients (p < 0.05). Ventilator-free days were 7 +/- 8 and 1 +/- 2 d in the more protected and less protected patients, respectively (p = 0.01). Plateau pressure ranged between 25 and 26 cm H(2)O in the more protected patients and between 28 and 30 cm H(2)O in the less protected patients (p = 0.006). Limiting tidal volume to 6 ml/kg predicted body weight and plateau pressure to 30 cm H(2)O may not be sufficient in patients characterized by a larger nonaerated compartment.

0 comments Cited 224 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: a report from the SHOCK trial registry.

N Slater, Venu Menon, Ryan G. Webb … (2004)

We sought to analyze clinical, angiographic, and outcome correlates of hemodynamic parameters in cardiogenic shock. The significance of right heart catheterization in critically ill patients is controversial, despite the prognostic importance of the derived measurements. Cardiac power is a novel hemodynamic parameter. A total of 541 patients with cardiogenic shock who were enrolled in the SHould we emergently revascularize Occluded Coronaries for cardiogenic shocK (SHOCK) trial registry were included. Cardiac power output (CPO) (W) was calculated as mean arterial pressure x cardiac output/451. On univariate analysis, CPO, cardiac power index (CPI), cardiac output, cardiac index, stroke volume, left ventricular work, left ventricular work index, stroke work, mean arterial pressure, systolic and diastolic blood pressure (all p < 0.001), coronary perfusion pressure (p = 0.002), ejection fraction (p = 0.013), and pulmonary artery systolic pressure (p = 0.047) were associated with in-hospital mortality. In separate multivariate analyses, CPO (odds ratio per 0.20 W: 0.60 [95% confidence interval, 0.44 to 0.83], p = 0.002; n = 181) and CPI (odds ratio per 0.10 W/m(2): 0.65 [95% confidence interval, 0.48 to 0.87], p = 0.004; n = 178) remained the strongest independent hemodynamic correlates of in-hospital mortality after adjusting for age and history of hypertension. There was an inverse correlation between CPI and age (correlation coefficient: -0.334, p < 0.001). Women had a lower CPI than men (0.29 +/- 0.11 vs. 0.35 +/- 0.15 W/m(2), p = 0.005). After adjusting for age, female gender remained associated with CPI (p = 0.032). Cardiac power is the strongest independent hemodynamic correlate of in-hospital mortality in patients with cardiogenic shock. Increasing age and female gender are independently associated with lower cardiac power.

0 comments Cited 170 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

SciELO Spain ID:: S0210-56912012000200003

License:

http://creativecommons.org/licenses/by-nc/4.0/

Keywords: Ventilación mecánica,Síndrome de distrés respiratorio agudo,Reclutamiento pulmonar,Presión al final de la espiración,Gasto cardiaco,Precarga,Monitorización hemodinámica,Mechanical ventilation,Acute respiratory distress syndrome,Lung recruitment maneuver,Positive end-expiratory pressure,Cardiac output,Preload,Hemodynamic monitoring

Cambios respiratorios y hemodinámicos durante una maniobra de reclutamiento pulmonar mediante incrementos y decrementos progresivos de PEEP

Read this article at

Abstract

Related collections

SciELO Spain

Most cited references 80

Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.

Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome.

Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: a report from the SHOCK trial registry.

Author and article information

Journal

Comments

Comment on this article

Similar content 468

Cited by 4

Most referenced authors 541