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      Exercise Dose in Clinical Practice

      research-article
      Author(s): , MD 1 , , MD 1
      Publication date PMC-release:
      Journal: Circulation
      Keywords: hypertension, lipids, exercise, mortality

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          Abstract

          There is wide variability in the physical activity patterns of the patients in contemporary clinical cardiovascular practice. This review is designed to address the impact of exercise dose on key cardiovascular risk factors and on mortality. We begin by examining the body of literature that supports a dose-response relationship between exercise and cardiovascular disease risk factors including plasma lipids, hypertension, diabetes mellitus, and obesity. We next explore the relationship between exercise dose and mortality by reviewing the relevant epidemiological literature underlying current physical activity guideline recommendations. We then expand this discussion to critically examine recent data pertaining to the impact of exercise dose at the lowest and highest ends of the spectrum. Finally, we provide a framework for how the key concepts of exercise dose can be integrated into clinical practice.

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          Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

          Paul Nathan, Elizabeth Barrett, John M. Lachin … (2002)
          Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible. We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes. We randomly assigned 3234 nondiabetic persons with elevated fasting and post-load plasma glucose concentrations to placebo, metformin (850 mg twice daily), or a lifestyle-modification program with the goals of at least a 7 percent weight loss and at least 150 minutes of physical activity per week. The mean age of the participants was 51 years, and the mean body-mass index (the weight in kilograms divided by the square of the height in meters) was 34.0; 68 percent were women, and 45 percent were members of minority groups. The average follow-up was 2.8 years. The incidence of diabetes was 11.0, 7.8, and 4.8 cases per 100 person-years in the placebo, metformin, and lifestyle groups, respectively. The lifestyle intervention reduced the incidence by 58 percent (95 percent confidence interval, 48 to 66 percent) and metformin by 31 percent (95 percent confidence interval, 17 to 43 percent), as compared with placebo; the lifestyle intervention was significantly more effective than metformin. To prevent one case of diabetes during a period of three years, 6.9 persons would have to participate in the lifestyle-intervention program, and 13.9 would have to receive metformin. Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin.
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            Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance

            Jaakko Tuomilehto, Jaana Lindström, Johan Eriksson … (2001)
            New England Journal of Medicine, 344(18), 1343-1350
            Article 0 comments Cited 633 times – based on 0 reviews     Review now
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              Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis.

              Aviroop Biswas, Paul I Oh, Guy E J Faulkner … (2015)
              The magnitude, consistency, and manner of association between sedentary time and outcomes independent of physical activity remain unclear. To quantify the association between sedentary time and hospitalizations, all-cause mortality, cardiovascular disease, diabetes, and cancer in adults independent of physical activity. English-language studies in MEDLINE, PubMed, EMBASE, CINAHL, Cochrane Library, Web of Knowledge, and Google Scholar databases were searched through August 2014 with hand-searching of in-text citations and no publication date limitations. Studies assessing sedentary behavior in adults, adjusted for physical activity and correlated to at least 1 outcome. Two independent reviewers performed data abstraction and quality assessment, and a third reviewer resolved inconsistencies. Forty-seven articles met our eligibility criteria. Meta-analyses were performed on outcomes for cardiovascular disease and diabetes (14 studies), cancer (14 studies), and all-cause mortality (13 studies). Prospective cohort designs were used in all but 3 studies; sedentary times were quantified using self-report in all but 1 study. Significant hazard ratio (HR) associations were found with all-cause mortality (HR, 1.240 [95% CI, 1.090 to 1.410]), cardiovascular disease mortality (HR, 1.179 [CI, 1.106 to 1.257]), cardiovascular disease incidence (HR, 1.143 [CI, 1.002 to 1.729]), cancer mortality (HR, 1.173 [CI, 1.108 to 1.242]), cancer incidence (HR, 1.130 [CI, 1.053 to 1.213]), and type 2 diabetes incidence (HR, 1.910 [CI, 1.642 to 2.222]). Hazard ratios associated with sedentary time and outcomes were generally more pronounced at lower levels of physical activity than at higher levels. There was marked heterogeneity in research designs and the assessment of sedentary time and physical activity. Prolonged sedentary time was independently associated with deleterious health outcomes regardless of physical activity. None.
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                Author and article information

                Journal
                Journal ID (nlm-journal-id): 0147763
                Journal ID (pubmed-jr-id): 2979
                Journal ID (nlm-ta): Circulation
                Journal ID (iso-abbrev): Circulation
                Title: Circulation
                ISSN (Print): 0009-7322
                ISSN (Electronic): 1524-4539
                Publication date Nihms-submitted: 30 May 2016
                Publication date (Print): 7 June 2016
                Publication date PMC-release: 07 June 2017
                Volume: 133
                Issue: 23
                Pages: 2297-2313
                Affiliations
                [1 ]Cardiovascular Performance Program, Massachusetts General Hospital, Boston, MA
                Author notes
                Address for Correspondence: Aaron L. Baggish, MD, Cardiovascular Performance Program, Massachusetts General Hospital, Yawkey Suite 5B, 55 Fruit St., Boston, MA 02114, Tel: 617-643-7117 Fax: 617-643-7222, abaggish@ 123456partners.org
                Article
                Accession ID: PMC4902280 Pmcid ID: PMC4902280 Pmc-uid ID: 4902280 Manuscript ID: nihpa782779
                DOI: 10.1161/CIRCULATIONAHA.116.018093
                PMC ID: 4902280
                PubMed ID: 27267537
                SO-VID: 883b5d37-1a0a-4fce-8ac5-cb8589727169
                History
                Categories
                Subject: Article

                Keywords: hypertension,mortality,exercise,lipids
                Data availability:
                Keywords: hypertension, mortality, exercise, lipids

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