Metal-Organic Framework-Based Stimuli-Responsive Systems for Drug Delivery.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

With the rapid development of nanotechnology, stimuli-responsive nanomaterials have provided an alternative for designing controllable drug delivery systems due to their spatiotemporally controllable properties. As a new type of porous material, metal-organic frameworks (MOFs) have been widely used in biomedical applications, especially drug delivery systems, owing to their tunable pore size, high surface area and pore volume, and easy surface modification. Here, recent progress in MOF-based stimuli-responsive systems is presented, including pH-, magnetic-, ion-, temperature-, pressure-, light-, humidity-, redox-, and multiple stimuli-responsive systems for the delivery of anticancer drugs. The remaining challenges and suggestions for future directions for the rational design of MOF-based nanomedicines are also discussed.

Related collections

Most cited references 17

Record: found
Abstract: found
Article: not found

Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery.

Challa S.S.R. Kumar, Faruq Mohammad (2011)

Previous attempts to review the literature on magnetic nanomaterials for hyperthermia-based therapy focused primarily on magnetic fluid hyperthermia (MFH) using mono metallic/metal oxide nanoparticles. The term "hyperthermia" in the literature was also confined only to include use of heat for therapeutic applications. Recently, there have been a number of publications demonstrating magnetic nanoparticle-based hyperthermia to generate local heat resulting in the release of drugs either bound to the magnetic nanoparticle or encapsulated within polymeric matrices. In this review article, we present a case for broadening the meaning of the term "hyperthermia" by including thermotherapy as well as magnetically modulated controlled drug delivery. We provide a classification for controlled drug delivery using hyperthermia: Hyperthermia-based controlled drug delivery through bond breaking (DBB) and hyperthermia-based controlled drug delivery through enhanced permeability (DEP). The review also covers, for the first time, core-shell type magnetic nanomaterials, especially nanoshells prepared using layer-by-layer self-assembly, for the application of hyperthermia-based therapy and controlled drug delivery. The highlight of the review article is to portray potential opportunities for the combination of hyperthermia-based therapy and controlled drug release paradigms--towards successful application in personalized medicine. Copyright © 2011 Elsevier B.V. All rights reserved.

0 comments Cited 329 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Multifunctional Efficiency: Extending the Concept of Atom Economy to Functional Nanomaterials.

Ralph Freund, Tobias Gruber, Ulrich Lächelt … (2018)

Green chemistry, in particular, the principle of atom economy, has defined new criteria for the efficient and sustainable production of synthetic compounds. In complex nanomaterials, the number of embedded functional entities and the energy expenditure of the assembly process represent additional compound-associated parameters that can be evaluated from an economic viewpoint. In this Perspective, we extend the principle of atom economy to the study and characterization of multifunctionality in nanocarriers, which we define as "multifunctional efficiency". This concept focuses on the design of highly active nanomaterials by maximizing integrated functional building units while minimizing inactive components. Furthermore, synthetic strategies aim to minimize the number of steps and unique reagents required to make multifunctional nanocarriers. The ultimate goal is to synthesize a nanocarrier that is highly specialized but practical and simple to make. Owing to straightforward crystal engineering, metal-organic framework (MOF) nanoparticles are an excellent example to illustrate the idea behind this concept and have the potential to emerge as next-generation drug delivery systems. Here, we highlight examples showing how the combination of the properties of MOFs ( e.g., their organic-inorganic hybrid nature, high surface area, and biodegradability) and induced systematic modifications and functionalizations of the MOF's scaffold itself lead to a nanocarrier with high multifunctional efficiency.