Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.

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Abstract

Respiratory syncytial virus (RSV)- and rhinovirus (RV)-induced bronchiolitis are associated with an increased risk of asthma, but more detailed information is needed on virus types.

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Most cited references 34

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Viral Bronchiolitis in Children

Julie Ingelfinger, H Meissner (2016)

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A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.

Klaus Bønnelykke, Patrick A. Sleiman, Kasper Nielsen … (2014)

Asthma exacerbations are among the most frequent causes of hospitalization during childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide association study of a specific asthma phenotype characterized by recurrent, severe exacerbations occurring between 2 and 6 years of age in a total of 1,173 cases and 2,522 controls. Cases were identified from national health registries of hospitalization, and DNA was obtained from the Danish Neonatal Screening Biobank. We identified five loci with genome-wide significant association. Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. We also obtained strong evidence for a new susceptibility gene, CDHR3 (encoding cadherin-related family member 3), which is highly expressed in airway epithelium. These results demonstrate the strength of applying specific phenotyping in the search for asthma susceptibility genes.

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Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.

Minal Çalışkan, Yury Bochkov, Eskil Kreiner-Møller … (2013)

Both genetic variation at the 17q21 locus and virus-induced respiratory wheezing illnesses are associated with the development of asthma. Our aim was to determine the effects of these two factors on the risk of asthma in the Childhood Origins of Asthma (COAST) and the Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohorts. We tested genotypes at the 17q21 locus for associations with asthma and with human rhinovirus (HRV) and respiratory syncytial virus (RSV) wheezing illnesses and tested for interactions between 17q21 genotypes and HRV and RSV wheezing illnesses with respect to the risk of asthma. Finally, we examined genotype-specific expression of 17q21 genes in unstimulated and HRV-stimulated peripheral-blood mononuclear cells (PBMCs). The 17q21 variants were associated with HRV wheezing illnesses in early life, but not with RSV wheezing illnesses. The associations of 17q21 variants with asthma were restricted to children who had had HRV wheezing illnesses, resulting in a significant interaction effect with respect to the risk of asthma. Moreover, the expression levels of ORMDL3 and of GSDMB were significantly increased in HRV-stimulated PBMCs, as compared with unstimulated PBMCs. The expression of these genes was associated with 17q21 variants in both conditions, although the increase with exposure to HRV was not genotype-specific. Variants at the 17q21 locus were associated with asthma in children who had had HRV wheezing illnesses and with expression of two genes at this locus. The expression levels of both genes increased in response to HRV stimulation, although the relative increase was not associated with the 17q21 genotypes. (Funded by the National Institutes of Health.).

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Author and article information

Journal

Journal ID (iso-abbrev): J Allergy Clin Immunol Pract

Title: The journal of allergy and clinical immunology. In practice

Publisher: Elsevier BV

ISSN (Electronic): 2213-2201

Publication date (Electronic): Feb 2020

Volume: 8

Issue: 2

Affiliations

[1 ] Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland; Department of Pediatrics, Central Hospital of Central Finland, Jyväskylä, Finland.

[2 ] Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.

[3 ] Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.

[4 ] Center for Child Health Research, University of Tampere, Tampere, Finland; Tampere University Hospital, Tampere, Finland.

[5 ] Departments of Molecular Virology and Microbiology and Pediatrics, Baylor College of Medicine, Houston, Texas.

[6 ] Departments of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

[7 ] Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

[8 ] Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland. Electronic address: tuomas.jartti@utu.fi.

Article

Publisher Item ID: S2213-2198(19)30768-8 Mid ID: NIHMS1059861

DOI: 10.1016/j.jaip.2019.08.043

PMC ID: 7012669

PubMed ID: 31520837

SO-VID: dabe3e02-a5e5-495e-928d-34fb64574bce

History

Keywords: Asthma development,Bronchiolitis,Respiratory syncytial virus,Rhinovirus,Wheeze,Wheezing

Data availability:

Keywords: Asthma development, Bronchiolitis, Respiratory syncytial virus, Rhinovirus, Wheeze, Wheezing

Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.

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Abstract

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Most cited references 34

Viral Bronchiolitis in Children

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.

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