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      The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma.

      Neurosurgical Review
      Craniopharyngioma, radiotherapy, surgery, Dose Fractionation, Humans, Pituitary Neoplasms, Radiosurgery, adverse effects, methods, Time Factors, Treatment Outcome

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          Abstract

          The optimal management of craniopharyngiomas remains controversial. The first-line treatment usually consists of surgical resection. Complete tumor removal provides a high rate of long-term control; however, aggressive surgery is associated with significant incidence of complications. Radiotherapy (RT) is currently used in patients after limited surgery and achieves excellent long-term tumor control. Stereotactic radiotherapy, both in the form of radiosurgery (RS) or fractionated stereotactic radiotherapy (FSRT), has been developed as a more accurate technique of irradiation with more precise tumor localization and consequently a reduction in the volume of normal brain irradiated to high radiation doses. We provide a review of published data on outcome of conventional fractionated RT and modern radiation techniques. FSRT is a suitable treatment technique for all sizes of craniopharyngiomas, and efficacy is comparable to conventional RT. Single-fraction stereotactic radiosurgery is usually delivered to small tumors away from critical structures. Longer follow-up is necessary to confirm the excellent tumor control and the potential reduction of long-term radiation toxicity.

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          Author and article information

          Journal
          19165514
          10.1007/s10143-009-0186-4

          Chemistry
          Craniopharyngioma,radiotherapy,surgery,Dose Fractionation,Humans,Pituitary Neoplasms,Radiosurgery,adverse effects,methods,Time Factors,Treatment Outcome

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