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      Allogeneic Hematopoietic Cell Transplantation for Aggressive NK-cell Leukemia. A CIBMTR Analysis

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          Abstract

          Aggressive NK-cell leukemia (ANKL) is an exceedingly rare form of leukemia and carries a poor prognosis with a median survival of only 2-months. Using the Center for International Blood and Marrow Transplant Research database, we evaluated outcomes of allogeneic hematopoietic cell transplantation (alloHCT) in patients with ANKL. Twenty-one patients with a centrally confirmed diagnosis of ANKL were included. Median patient age was 42-years and 15 patients (71%) were Caucasian. Fourteen patients (67%) were in complete remission (CR) at the time of alloHCT, while 5 patients had active disease. Median follow-up of survivors was 25 months (range: 12–116). The 2-year estimates of non-relapse mortality, relapse/progression, progression-free (PFS) and overall survival (OS) were 21%, 59%, 20% and 24%, respectively. The 2-year PFS of patients in CR at the time of alloHCT was significantly better than that of patients with active disease at transplantation (30% vs. 0%; p=0.001). The 2-year OS in similar order was 38% vs. 0% (p<0.001). In conclusion, this registry analysis that included majority non-Asian patient population shows that alloHCT can provide durable disease control in a subset of ANKL patients. Achieving CR before transplantation appears to be a prerequisite for successful transplantation outcomes.

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          Author and article information

          Journal
          9600628
          20830
          Biol Blood Marrow Transplant
          Biol. Blood Marrow Transplant.
          Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
          1083-8791
          1523-6536
          18 March 2017
          01 February 2017
          May 2017
          01 May 2018
          : 23
          : 5
          : 853-856
          Affiliations
          [1 ]CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
          [2 ]Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
          [3 ]Osborn Hematopoietic Malignancy and Transplantation Program, West Virginia University, Morgantown, WV
          [4 ]Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI
          [5 ]Section of Hematology/Oncology, The University of Chicago, Chicago, IL
          [6 ]Division of Hematology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea
          [7 ]Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
          [8 ]Division of Cell Therapy and Hematologica, Department of Medicine, Duke University Medical Center, Durham, NC
          [9 ]The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
          [10 ]NIH-NCI Experimental Transplantation and Immunology Branch, Bethesda, MD
          [11 ]BMT Unit, Department of Hematology, Rigshospitalet, Copenhagen, Denmark
          [12 ]Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA
          [13 ]University of Iowa Hospitals & Clinics, Iowa City, IA
          [14 ]Hematological Malignancy/Stem Cell Transplant Program, David Geffen School of Medicine at UCLA, Los Angeles, CA
          [15 ]Blood & Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine, Greenebaum Cancer Center, University of Maryland, Baltimore, MD
          [16 ]Hematology Department, Institut Català d’Oncologia - Hospitalet, Barcelona, Spain
          [17 ]Department of Pathology, Medical College of Wisconsin, Milwaukee, WI
          Author notes
          Corresponding author: Mehdi Hamadani, MD, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Suite C5500, Milwaukee, WI 53226, USA; Phone: 414-805-0643; Fax: 414-805-0714; mhamadani@ 123456mcw.edu
          Article
          PMC5410937 PMC5410937 5410937 nihpa859159
          10.1016/j.bbmt.2017.01.082
          5410937
          28161608
          4aa5e438-6ff5-4464-91b9-e72cffaf842b
          History
          Categories
          Article

          allogeneic transplant,Aggressive NK-cell leukemia,myeloablative,reduced intensity conditioning

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