Breast implant seroma: A SARS‐CoV ‐2 mRNA vaccine side effect

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Abstract

<p id="d2160047e253">Fluid collection surrounding breast implants, called seroma, is a frequent issue that has diverse etiologies. We describe a 48‐year‐old woman with an acute onset of bilateral breast swelling occurring 5 years after aesthetic surgery and 10 days after a second SARS‐CoV‐2 mRNA vaccine dose. At breast ultrasound, we found an abundant bilateral peri‐implant seroma. Our patient noticed symptom improvement 48 h after nonsteroidal anti‐inflammatory drug treatment, complete disappearance of symptoms after 10 days with seroma disappearance documented by ultrasound. We hypothesized a breast implant seroma as post‐SARS‐CoV‐2 mRNA vaccine side effect, as different other diagnosis had been excluded. </p>

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Most cited references 12

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Cellular and molecular composition of fibrous capsules formed around silicone breast implants with special focus on local immune reactions.

W Georg, Niederegger Harald, Georg Wick … (2004)

During the past 30 years, much debate has centered around side effects of silicone breast implants. Meta-analyses rejected the presumed relationship between silicone breast implants and connective tissues diseases but, in seeming contradiction, case reports about connective tissue diseases and rheumatoid symptoms continue to be published. We analyzed the cellular and molecular composition of fibrous capsules removed from patients at various times after surgery for diagnostic purposes (breast cancer relapse) or to relieve painful constrictive fibrosis. Frozen sections of capsule tissue were immunohistochemically stained for subsets of lymphocytes, macrophages, dendritic cells, fibroblasts, smooth muscle cells, for collagenous and non-collagenous extracellular matrix proteins, for heat shock protein 60 (HSP60) and for adhesion molecules. Massive deposition of fibronectin and tenascin was observed adjacent to the implant surface. The capsule/silicone implant contact zone was consistently characterized by a palisade-like single or multilayered cell accumulation consisting of HSP60+ macrophages and HSP60+ fibroblasts. Mononuclear cell infiltrates consisting of activated CD4+ T-cells, expressing CD25 and CD45RO, as well as macrophages were detected beneath the contact zone as well as perivascularly. Importantly, many Langerhans-cell like dendritic cells (DCs) were found with a predilection at the frontier layer zone abutting the silicone implant. Also, at this site, massive expression of ICAM-1, but not VCAM-1 or ELAM-1 emerged. Endothelial cells of the intracapsular neovasculature were P-Selectin+. Our results show that silicone induces a strong local T-cell immune response and future studies will determine the specificity and function of these T-lymphocytes. Copyright 2004 Elsevier Ltd.

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Late hematoma after breast implantation.

Michael Brickman, Natalie Parsa, Fereydoun Don Parsa (2004)

The case of a patient who experienced a late, spontaneous breast hematoma 9 years after augmentation mammaplasty in the absence of trauma or anticoagulation is reported. Although hematoma is not an uncommon complication in the immediate postoperative period, it is very rare as a late complication of breast implantation. A review of the literature suggested that a chronic inflammatory reaction to the polyurethane-coated implants used in the reported patient was the most likely cause for the complication.