For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
9
views
6
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      369
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Late Seroma in Breast Implants: A Coronavirus Disease 2019 Phenomenon?

      research-article
      Author(s): , MBBS, MRCS, MMed, FAMS 1 , , MBBS, MRCS, MMed, FAMS 1
      Publication date (Electronic):
      Journal: Archives of Plastic Surgery
      Publisher: Thieme Medical Publishers, Inc.
      Keywords: late seroma, seroma, breast implant, coronavirus, coronavirus disease 2019

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The coronavirus disease 2019 (COVID-19) pandemic has been challenging in all aspects of the medical field with new clinical presentations constantly arising. Plastic surgeons are not immune to this and need to be aware of their implications. There has been a recent report of late periprosthetic seroma (breast implant) as a clinical manifestation of COVID-19 infection. To our knowledge, this phenomenon has not been further reported. We present a 53-year-old immunocompromised lady who developed late seroma after COVID-19 infection. She eventually required explantation of the implant and is awaiting autologous reconstruction. It is likely that we will increasingly continue to see this phenomenon of implant complications as a result of COVID-19 infection and should be watchful, especially regarding potential immunocompromised patients.

          Related collections

          Most cited references6

          • Record: found
          • Abstract: found
          • Article: not found

          “ COVID-19/SARS-CoV-2 virus spike protein-related delayed inflammatory reaction to hyaluronic acid dermal fillers: a challenging clinical conundrum in diagnosis and treatment”

          Girish Gilly Munavalli, Rachel Guthridge, Siri Knutsen-Larson … (2021)
          We present the first reported cases of delayed inflammatory reactions (DIR) to hyaluronic acid (HA) dermal fillers after exposure to the COVID-19 spike protein. DIR to HA is reported to occur in the different scenarios including: secondary to poor injection technique, following dental cleaning procedures, following bacterial/viral illness, and after vaccination. In this report of 4 cases with distinct clinical histories and presentations: one case occured following a community acquired COVID-19 infection, one case occured in a study subject in the mRNA-1273 clinical phase III trial, one case occurred following the first dose of publically available mRNA-1273 vaccine (Moderna, Cambridge MA), and the last case occurred after the second dose of BNT162b2 vaccine (Pfizer, New York, NY). Injectable HA dermal fillers are prevalent in aesthetic medicine for facial rejuvenation. Structural modifications in the crosslinking of HA fillers have enhanced the products’ resistance to enzymatic breakdown and thus increased injected product longevity, however, have also led to a rise in DIR. Previous, DIR to HA dermal fillers can present clinically as edema with symptomatic and inflammatory erythematous papules and nodules. The mechanism of action for the delayed reaction to HA fillers is unknown and is likely to be multifactorial in nature. A potential mechanism of DIR to HA fillers in COVID-19 related cases is binding and blockade of angiotensin 2 converting enzyme receptors (ACE2), which are targeted by the SARS-CoV-2 virus spike protein to gain entry into the cell. Spike protein interaction with dermal ACE2 receptors favors a pro-inflammatory, loco-regional TH1 cascade, promoting a CD8+T cell mediated reaction to incipient granulomas, which previously formed around residual HA particles. Management to suppress the inflammatory response in the native COVID-19 case required high-dose corticosteroids (CS) to suppress inflammatory pathways, with concurrent ACE2 upregulation, along with high-dose intralesional hyaluronidase to dissolve the inciting HA filler. With regards to the two vaccine related cases; in the mRNA-1273 case, a low dose angiotensin converting enzyme inhibitor (ACE-I) was utilized for treatment, to reduce pro-inflammatory Angiotensin II. Whereas, in the BNT162b2 case the filler reaction was suppressed with oral corticosteroids. Regarding final disposition of the cases; the vaccine-related cases returned to baseline appearance within 3 days, whereas the native COVID-19 case continued to have migratory, evanescent, periorbital edema for weeks which ultimately subsided.
          Article 0 comments Cited 36 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Potential immune response to breast implants after immunization with COVID-19 vaccines

            Laurenz Weitgasser, Maximilian M. Mahrhofer, Thomas Schoeller (2021)
            Besides reports of alarming potential side effects after COVID-19 vaccinations there have been rare observations of rather benign reactions to foreign materials such as cosmetic hyaluronic acid filler injections after a COVID-19 immunization. Likewise to dermal fillers any foreign material may cause a reaction when the immune system is triggered. In the recent weeks we observed four noteworthy potential reactions in association with breast implants between one and three days after COVID-19 vaccinations. We release these information at the earliest to educate colleagues and draw attention to possible reactions between the COVID-19 vaccines and foreign bodies such as breast implants.
            Article 0 comments Cited 11 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              A Case Report of Capsular Contracture Immediately Following Covid-19 Vaccination

              Richard J Restifo (2021)
              Capsular contracture is fundamentally an immunological/inflammatory response to the implant, treating it as a foreign body in need of exclusion from the immune system. The capsule surrounding the implant is populated by a rich variety of immunologically active cells such as macrophages, T lymphocytes, and myofibroblasts. Vaccination in general and the Covid-19 vaccine in particular result in specific and nonspecific activation of the immune system, including those immune cells in proximity to the implant. This phenomenon has been previously demonstrated in delayed inflammatory reactions to previously implanted hyaluronic acid fillers following Covid 19 vaccination. This report is what is believed to be the first case of the rapid development of severe ipsilateral capsular contracture in the immediate aftermath of the second dose of the BNT162b2(Pfizer) vaccine.
              Article 0 comments Cited 8 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Arch Plast Surg
                Journal ID (iso-abbrev): Arch Plast Surg
                Journal ID (doi): 10.1055/s-00051611
                Title: Archives of Plastic Surgery
                Publisher: Thieme Medical Publishers, Inc. (333 Seventh Avenue, 18th Floor, New York, NY 10001, USA )
                ISSN (Print): 2234-6163
                ISSN (Electronic): 2234-6171
                Publication date (Electronic): 23 September 2022
                Publication date Collection: September 2022
                Publication date PMC-release: 1 September 2022
                Volume: 49
                Issue: 5
                Pages: 611-613
                Affiliations
                [1 ]Department of Plastic, Reconstructive and Aesthetic Surgery, KK Women's and Children's Hospital, Singapore
                Author notes
                Address for correspondence Wan Loong James Mok, MBBS, MRCS, MMed, FAMS Department of Plastic, Reconstructive and Aesthetic Surgery, KK Women's and Children's Hospital Level 5 Women's Tower, 100 Bukit Timah Road, Singapore 229899Singapore james.mok.w.l@ 123456singhealth.com.sg
                Author information
                http://orcid.org/0000-0002-4818-5951
                http://orcid.org/0000-0001-9476-1318
                Article
                Publisher ID: aps-21-314
                DOI: 10.1055/s-0042-1756295
                PMC ID: 9507605
                PubMed ID: 36159375
                SO-VID: 92a89b84-0352-4f90-87be-502984548a0f
                Copyright © The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

                History
                Date received : 08 December 2021
                Date accepted : 07 July 2022
                Categories
                Subject: Breast/Trunk: Case Report

                ScienceOpen disciplines: Surgery
                Keywords: late seroma,seroma,breast implant,coronavirus,coronavirus disease 2019
                Data availability:
                ScienceOpen disciplines: Surgery
                Keywords: late seroma, seroma, breast implant, coronavirus, coronavirus disease 2019

                Comments

                Comment on this article

                scite_

                Similar content369

                See all similar

                Cited by1

                See all cited by

                Most referenced authors25

                See all reference authors