The purpose of this introductory chapter is to set the scene for this handbook of research. The authors begin by briefly explaining how different fields within the literature have tended to operate independently. Even within fields, distinct research groups often work in silos, limiting intradisciplinary and interdisciplinary knowledge sharing. Next, the authors introduce and define the construct of ‘sustainable career ecosystems' as an opportunity to provide a framework for a more collaborative research agenda. The chapter concludes by giving a brief overview of the current state of play, identifying some of the challenges, and initiating the process of searching for solutions across the three key sections addressed by this handbook of research, (i) higher education and graduate employability, (ii) organizations and graduate employment, and (iii) sustainable careers and the future of work.