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Abstract

Diabetes mellitus (DM) is a chronic health problem that increases the risk of infection and delays wound healing due to impairment of metabolic activity. Diabetic foot ulcers (DFUs), a chronic wound increases the risk of mortality. Finding the most appropriate wound dressings has been intensified with the increasing population and prevalence of chronic wounds. Nanofibers coated wound dressings have attracted more attention as innovative and biocompatible materials. Nanocellulose (NC) has been widely used as a reinforcing material to improve nanofibers’ mechanical and thermal properties. NC is biodegradable and derived from renewable sources and produced bionanocomposites with improved performance.

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Cellulose nanomaterials review: structure, properties and nanocomposites.

Robert Moon, Ashlie Martini, John Nairn … (2011)

This critical review provides a processing-structure-property perspective on recent advances in cellulose nanoparticles and composites produced from them. It summarizes cellulose nanoparticles in terms of particle morphology, crystal structure, and properties. Also described are the self-assembly and rheological properties of cellulose nanoparticle suspensions. The methodology of composite processing and resulting properties are fully covered, with an emphasis on neat and high fraction cellulose composites. Additionally, advances in predictive modeling from molecular dynamic simulations of crystalline cellulose to the continuum modeling of composites made with such particles are reviewed (392 references).

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Chronic Wound Healing: A Review of Current Management and Treatments

George Han, Roger I Ceilley (2017)

Wound healing is a complex, highly regulated process that is critical in maintaining the barrier function of skin. With numerous disease processes, the cascade of events involved in wound healing can be affected, resulting in chronic, non-healing wounds that subject the patient to significant discomfort and distress while draining the medical system of an enormous amount of resources. The healing of a superficial wound requires many factors to work in concert, and wound dressings and treatments have evolved considerably to address possible barriers to wound healing, ranging from infection to hypoxia. Even optimally, wound tissue never reaches its pre-injured strength and multiple aberrant healing states can result in chronic non-healing wounds. This article will review wound healing physiology and discuss current approaches for treating a wound.

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Inflammation and wound healing: the role of the macrophage.

Timothy J. Koh, Luisa DiPietro (2011)

The macrophage is a prominent inflammatory cell in wounds, but its role in healing remains incompletely understood. Macrophages have many functions in wounds, including host defence, the promotion and resolution of inflammation, the removal of apoptotic cells, and the support of cell proliferation and tissue restoration following injury. Recent studies suggest that macrophages exist in several different phenotypic states within the healing wound and that the influence of these cells on each stage of repair varies with the specific phenotype. Although the macrophage is beneficial to the repair of normally healing wounds, this pleotropic cell type may promote excessive inflammation or fibrosis under certain circumstances. Emerging evidence suggests that macrophage dysfunction is a component of the pathogenesis of nonhealing and poorly healing wounds. As a result of advances in the understanding of this multifunctional cell, the macrophage continues to be an attractive therapeutic target, both to reduce fibrosis and scarring, and to improve healing of chronic wounds.

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Publication date (Online): May 10 2023

DOI: 10.5772/intechopen.104158

SO-VID: 457a0379-c43f-4cc4-98a4-66c9bb4e8c37

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Application of Nanocellulose Biocomposites in Acceleration of Diabetic Wound Healing: Recent Advances and New Perspectives

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Most cited references 57

Cellulose nanomaterials review: structure, properties and nanocomposites.

Chronic Wound Healing: A Review of Current Management and Treatments

Inflammation and wound healing: the role of the macrophage.

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