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      Eco-friendly bio-nanocomposites: pioneering sustainable biomedical advancements in engineering

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          Abstract

          Biomedical nanocomposites, which are an upcoming breed of mischievous materials, have ushered in a new dimension in the healthcare sector. Incorporating these materials tends to boost features this component already possesses and give might to things these components could not withstand alone. The biopolymer, which carries the nanoparticles, can simultaneously improve the composite's stiffness and biological characteristics, and vice versa. This increases the options of the composite and the number of times it can be used. The bio-nanocomposites and nanoparticles enable the ecocompatibility of the medicine in their biodegradability, and they, in this way, have ecological sustainability. The outcome is the improved properties of medicine and its associated positive impact on the environment. They have broad applications in antimicrobial agents, drug carriers, tissue regeneration, wound care, dentistry, bioimaging, and bone filler, among others. The dissertation on the elements of bio-nanocomposites emphasizes production techniques, their diverse applications in medicine, match-up issues, and future-boasting prospects in the bio-nanocomposites field. Through the utilization of such materials, scientists can develop more suitable for the environment and healthy biomedical solutions, and world healthcare in this way improves as well.

          Highlights

          • Bio-nanocomposite composition explores the combination of natural biopolymers with nanoscale fillers.

          • These materials have enhanced mechanical strength, thermal stability, and biocompatibility, making them ideal for tissue engineering, drug delivery, and diagnostic imaging.

          • Their biodegradability and non-toxic nature minimize environmental impact, making them a game-changer in sustainable biomedical advancements.

          • Acknowledges potential issues and the need for further research to ensure compatibility with biological systems.

          • These materials can be easily tailored to specific requirements, enabling personalized medicine and targeted therapies.

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          Most cited references193

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          A review on chitosan and chitosan-based bionanocomposites: Promising material for combatting global issues and its applications

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            Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect

            Abstract Bacterial wound infection is one of the most common nosocomial infections. The unnecessary employment of antibiotics led to raising the growth of antibiotic‐resistant bacteria. Accordingly, alternative armaments capable of accelerating wound healing along with bactericidal effects are urgently needed. Considering this, we fabricated chitosan (CS)/polyethylene oxide (PEO) nanofibers armed with antibacterial silver and zinc oxide nanoparticles. The nanocomposites exhibited a high antioxidant effect and antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Besides, based on the results of the cell viability assays, the optimum concentration of ZnONPs and AgNPs in the nanofibrous mats is 0.2% w/v and 0.08% w/v respectively and had no cytotoxicity on fibroblast cells. The scaffold also showed good blood compatibility according to the effects of coagulation time. As well as significant fibroblast migration and proliferation on the wound margin, according to wound‐healing assay. All in all, the developed biocompatible, antioxidant, and antibacterial Ag‐ZnO NPs incorporated CS/PEO nanofibrous mats showed their potential as an effective wound dressing.
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              Pullulan-based nanocomposite films for functional food packaging: Exploiting lysozyme nanofibers as antibacterial and antioxidant reinforcing additives

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                Author and article information

                Contributors
                karthikeyanelumalai@hotmail.com , karthikeyane.scop@saveetha.com
                Journal
                Discov Nano
                Discov Nano
                Discover Nano
                Springer US (New York )
                2731-9229
                9 May 2024
                9 May 2024
                December 2024
                : 19
                : 1
                : 86
                Affiliations
                [1 ]Department of Pharmaceutics, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, ( https://ror.org/0232f6165) Chennai, 602105 India
                [2 ]GRID grid.412431.1, ISNI 0000 0004 0444 045X, Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, , Saveetha Institute of Medical and Technical Sciences, ; Chennai, 602105 Tamilnadu India
                [3 ]Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, ( https://ror.org/05a1xb650) Chennai, India
                Article
                4007
                10.1186/s11671-024-04007-7
                11082105
                38724698
                26b911f6-7f7b-4d91-bc93-d822944f50f8
                © The Author(s) 2024

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 17 January 2024
                : 8 April 2024
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                Review
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                © Springer Science+Business Media, LLC, part of Springer Nature 2024

                bio-nanocomposites,biopolymers,eco-friendly,biomedical,fabrication

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