Blood fibrocytes are recruited during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4-dependent pathway.

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Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by peribronchial fibrosis. The chronic course of COPD is worsened by recurrent acute exacerbations.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Allergy Clin. Immunol.

Title: The Journal of allergy and clinical immunology

Publisher: Elsevier BV

ISSN (Electronic): 1097-6825

ISSN (Print): 0091-6749

Publication date (Electronic): Apr 2016

Volume: 137

Issue: 4

Affiliations

[1 ] Univ-Bordeaux, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, Département de Pharmacologie, Bordeaux, France; INSERM, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, Département de Pharmacologie, Bordeaux, France. Electronic address: isabelle.dupin@u-bordeaux.fr.

[2 ] Univ-Bordeaux, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, Département de Pharmacologie, Bordeaux, France; INSERM, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, Département de Pharmacologie, Bordeaux, France.

[3 ] Univ-Bordeaux, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, Département de Pharmacologie, Bordeaux, France; INSERM, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, Département de Pharmacologie, Bordeaux, France; CHU de Bordeaux, Service d'exploration fonctionnelle respiratoire, Service de pneumologie, Services de réanimation médicale, Service de chirurgie thoracique, Pessac, France.

[4 ] CHU de Bordeaux, Service d'exploration fonctionnelle respiratoire, Service de pneumologie, Services de réanimation médicale, Service de chirurgie thoracique, Pessac, France.

[5 ] Univ-Bordeaux, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, Département de Pharmacologie, Bordeaux, France; INSERM, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, Département de Pharmacologie, Bordeaux, France; CHU de Bordeaux, Service d'exploration fonctionnelle respiratoire, Service de pneumologie, Services de réanimation médicale, Service de chirurgie thoracique, Pessac, France. Electronic address: patrick.berger@u-bordeaux.fr.

Article

Publisher Item ID: S0091-6749(15)01333-0

DOI: 10.1016/j.jaci.2015.08.043

PubMed ID: 26602164

SO-VID: fee97c6c-ead8-4605-a446-bf288b74ba58

History

Keywords: lung function,fibrocyte,chemotaxis,Chronic obstructive pulmonary disease,mortality

Data availability:

Keywords: lung function, fibrocyte, chemotaxis, Chronic obstructive pulmonary disease, mortality

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