The aim of this study was to evaluate the bond strength of different adhesive sealers on Resilon and gutta-percha. Pellets of gutta-percha and Resilon were embedded into test tubes. Small eyelets were attached to those surfaces with a 0.5-mm film of different root canal sealers. Real Seal, Real Seal SE, Hybrid Root Seal (also known as Meta Seal), and AH Plus were used. AH Plus as a nonadhesive sealer served as a control group. In all groups (n = 10) shear bond strength was measured. Shear bond strength was relatively low (0.1-3 MPa) and significantly higher in the groups with a single component adhesive sealer. No substantial bond strength was found in the control group. Overall bond strength to Resilon was higher than to gutta-percha but not significant compared with the Hybrid Root Seal group. With single component self-adhesive sealers, an adhesive connection might be formed to gutta-percha as well as to Resilon. Copyright (c) 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.