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      Association synchrone d'un cancer du sein bilatéral et d'une tumeur stromale gastro-intestinale: à propos d'un rare cas Translated title: Synchronous association of a bilateral breast cancer and a gastrointestinal stromal tumor: report of a rare case

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          Abstract

          Les tumeurs stromales gastro-intestinales sont les tumeurs mésenchymateuses les plus fréquentes, pourtant, leur association avec les tumeurs du sein sont rares, seulement quelques cas cliniques sont rapportés dans la littérature. Nous rapportons l'observation d'une jeune femme de 41 ans, suivie à l'institut national d'oncologie de Rabat, pour un carcinome canalaire du sein, bilatéral, chez qui le bilan d'extension a objectivé une tumeur stromale de type gastro-intestinale aux dépens de l'estomac. Nous décrivons à travers cette observation les aspects épidémiologiques, cliniques, et les particularités de la prise en charge de cette association rare.

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          Gastrointestinal stromal tumors of neurofibromatosis type I (von Recklinghausen's disease).

          Jun-ichi Yamaguchi, Yoshio Hashizume, Shinji Sakurai … (2005)
          Gastrointestinal stromal tumor (GIST), as well as the hyperplastic lesions of intestinal neural tissue and its supporting structures, is a gastrointestinal complication of type 1 neurofibromatosis (NF1) (von Recklinghausen's disease). In the present study, we analyzed the histologic and immunohistochemical features, and the c-kit and PDGFRA gene mutations of 36 GISTs derived from 9 NF1 patients. Distinctively, multiple GISTs arose preferentially in the small intestine. The histologic features of NF1-associated GISTs are almost similar to those of non-NF1 GISTs, but characteristically most of the NF1-associated GISTs contained skeinoid fibers. Thirty-three GISTs (92%) showed immunoreactivity for KIT, and 23 tumors (64%) showed diffuse or mosaic-like immunoreactivity for S-100 protein. Hyperplasic lesions, which may be the hyperplasia of interstitial cells of Cajal, were observed around some GISTs. Exons 9, 11, 13, and 17 of the c-kit gene and exons 12 and 18 of the PDGFRA gene were amplified and directly sequenced. Point mutations of c-kit gene or PDGFRA gene were identified only in three (8%) and two (6%) tumors, respectively. NF1-associated GISTs, showing the dual differentiation of interstitial cells of Cajal and Schwann cells, develop in close association with the myenteric nerve structure of gastrointestinal tract of NF1 patients. The point mutations of c-kit and PDGFRA gene may play a limited role in the tumorigenesis of NF1-associated GISTs.
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            Association of GIST, breast cancer and schwannoma in a 60-year-old woman affected by type-1 von Recklinghausen's neurofibromatosis.

            Roberta Invernizzi, Barbara Martinelli, Graziella Pinotti (2024)
            Neurofibromatosis (NF1 or von Recklinghausen's disease) is a common autosomal dominant disease associated with a higher incidence of neoplasms than in the general population. We report the case of a 60-year-old woman affected by NF1 who was coincidentally diagnosed with a gastrointestinal stromal tumor, a breast carcinoma and a peripheral nervous system tumor.
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              Synchronous double tumor of breast cancer and gastrointestinal stromal tumor in a patient with neurofibromatosis type 1: report of a case.

              Hideya Takeuchi, Shozi Hiroshige, Kenkichi Hashimoto … (2011)
              We report a rare case of synchronous double tumor formation of breast cancer and gastrointestinal stromal tumor (GIST) in a patient with neurofibromatosis type 1(NF-1). A 76-year-old woman with a history of NF-1 who had undergone left modified mastectomy for breast cancer seven years previously was admitted to our hospital because of a right breast tumor and abdominal discomfort. Computed tomography revealed an enhanced irregular tumor in the right breast and peripheral enhanced tumors in the abdomen. The patient underwent right modified mastectomy and laparoscopic tumor resection combined with small intestine surgery. Histopathological examination revealed the presence of invasive lobular carcinoma in the right breast and GIST in the abdomen. The synchronous development of breast cancer and GIST in a patient with NF-1 is extremely rare, with this being the second case ever reported.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Pan Afr Med J
                Journal ID (iso-abbrev): Pan Afr Med J
                Journal ID (publisher-id): PAMJ
                Title: The Pan African Medical Journal
                Publisher: The African Field Epidemiology Network
                ISSN (Electronic): 1937-8688
                Publication date (Electronic): 16 January 2015
                Publication date Collection: 2015
                Volume: 20
                Electronic Location Identifier: 45
                Affiliations
                [1 ]Service de Radiothérapie, Institut National d'Oncologie, Université Mohammed V, Rabat, Maroc
                [2 ]Service d'Oncologie Médicale, Institut National d'Oncologie, Université Mohammed V, Rabat, Maroc
                Author notes
                [& ]Corresponding author: Mohammed Afif, Service de Radiothérapie, Institut National d'Oncologie, Université Mohammed V, Rabat, Maroc
                Article
                Publisher ID: PAMJ-20-45
                DOI: 10.11604/pamj.2015.20.45.5771
                PMC ID: 4449977
                SO-VID: fe006a26-a7e4-4897-b6a8-d298fe1c6e4d
                Copyright © © Mohammed Afif et al.
                License:

                The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 15 November 2014
                Date accepted : 08 January 2015
                Categories
                Subject: Case Report

                ScienceOpen disciplines: Medicine
                Keywords: cancer du sein,tumeur stromale,association,rare,breast cancer,stromal tumor
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: cancer du sein, tumeur stromale, association, rare, breast cancer, stromal tumor

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