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      Clinical Interventions in Aging (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on prevention and treatment of diseases in people over 65 years of age. Sign up for email alerts here.

      36,334 Monthly downloads/views I 3.829 Impact Factor I 7.4 CiteScore I 1.83 Source Normalized Impact per Paper (SNIP) I 1.044 Scimago Journal & Country Rank (SJR)

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      Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

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          Abstract

          Purpose

          We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI).

          Patients and methods

          Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks.

          Results

          The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed.

          Conclusion

          The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

          Most cited references21

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          Long-term effects of cognitive training on everyday functional outcomes in older adults.

          Sherry L. Willis, Sharon L Tennstedt, Michael Marsiske … (2006)
          Cognitive training has been shown to improve cognitive abilities in older adults but the effects of cognitive training on everyday function have not been demonstrated. To determine the effects of cognitive training on daily function and durability of training on cognitive abilities. Five-year follow-up of a randomized controlled single-blind trial with 4 treatment groups. A volunteer sample of 2832 persons (mean age, 73.6 years; 26% black), living independently in 6 US cities, was recruited from senior housing, community centers, and hospitals and clinics. The study was conducted between April 1998 and December 2004. Five-year follow-up was completed in 67% of the sample. Ten-session training for memory (verbal episodic memory), reasoning (inductive reasoning), or speed of processing (visual search and identification); 4-session booster training at 11 and 35 months after training in a random sample of those who completed training. Self-reported and performance-based measures of daily function and cognitive abilities. The reasoning group reported significantly less difficulty in the instrumental activities of daily living (IADL) than the control group (effect size, 0.29; 99% confidence interval [CI], 0.03-0.55). Neither speed of processing training (effect size, 0.26; 99% CI, -0.002 to 0.51) nor memory training (effect size, 0.20; 99% CI, -0.06 to 0.46) had a significant effect on IADL. The booster training for the speed of processing group, but not for the other 2 groups, showed a significant effect on the performance-based functional measure of everyday speed of processing (effect size, 0.30; 99% CI, 0.08-0.52). No booster effects were seen for any of the groups for everyday problem-solving or self-reported difficulty in IADL. Each intervention maintained effects on its specific targeted cognitive ability through 5 years (memory: effect size, 0.23 [99% CI, 0.11-0.35]; reasoning: effect size, 0.26 [99% CI, 0.17-0.35]; speed of processing: effect size, 0.76 [99% CI, 0.62-0.90]). Booster training produced additional improvement with the reasoning intervention for reasoning performance (effect size, 0.28; 99% CI, 0.12-0.43) and the speed of processing intervention for speed of processing performance (effect size, 0.85; 99% CI, 0.61-1.09). Reasoning training resulted in less functional decline in self-reported IADL. Compared with the control group, cognitive training resulted in improved cognitive abilities specific to the abilities trained that continued 5 years after the initiation of the intervention. clinicaltrials.gov Identifier: NCT00298558.
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            A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study.

            Glenn Smith, Patricia Housen, Kristine Yaffe … (2009)
            To investigate the efficacy of a novel brain plasticity-based computerized cognitive training program in older adults and to evaluate the effect on untrained measures of memory and attention and participant-reported outcomes. Multisite randomized controlled double-blind trial with two treatment groups. Communities in northern and southern California and Minnesota. Community-dwelling adults aged 65 and older (N=487) without a diagnosis of clinically significant cognitive impairment. Participants were randomized to receive a broadly-available brain plasticity-based computerized cognitive training program (intervention) or a novelty- and intensity-matched general cognitive stimulation program modeling treatment as usual (active control). Duration of training was 1 hour per day, 5 days per week, for 8 weeks, for a total of 40 hours. The primary outcome was a composite score calculated from six subtests of the Repeatable Battery for the Assessment of Neuropsychological Status that use the auditory modality (RBANS Auditory Memory/Attention). Secondary measures were derived from performance on the experimental program, standardized neuropsychological assessments of memory and attention, and participant-reported outcomes. RBANS Auditory Memory/Attention improvement was significantly greater (P=.02) in the experimental group (3.9 points, 95% confidence interval (CI)=2.7-5.1) than in the control group (1.8 points, 95% CI=0.6-3.0). Multiple secondary measures of memory and attention showed significantly greater improvements in the experimental group (word list total score, word list delayed recall, digits backwards, letter-number sequencing; P<.05), as did the participant-reported outcome measure (P=.001). No advantage for the experimental group was seen in narrative memory. The experimental program improved generalized measures of memory and attention more than an active control program.
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              Does Cognitive Training Prevent Cognitive Decline?

              Mary Butler, Ellen McCreedy, Victoria Nelson … (2018)
              Structured activities to stimulate brain function-that is, cognitive training exercises-are promoted to slow or prevent cognitive decline, including dementia, but their effectiveness is highly debated.
              Article 0 comments Cited 84 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Clin Interv Aging
                Journal ID (iso-abbrev): Clin Interv Aging
                Journal ID (publisher-id): CIA
                Journal ID (pmc): clinintag
                Title: Clinical Interventions in Aging
                Publisher: Dove
                ISSN (Print): 1176-9092
                ISSN (Electronic): 1178-1998
                Publication date (Electronic): 28 June 2019
                Publication date Collection: 2019
                Volume: 14
                Pages: 1167-1175
                Affiliations
                [1 ] Department of Neurology, Haueundae Paik Hospital, Inje University , Busan, South Korea
                [2 ] Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute , Busan, South Korea
                [3 ] Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine , Seoul, South Korea
                [4 ] Department of Neurology, Bobath Memorial Hospital , Seongnam, South Korea
                [5 ] Department of Neurology, Inha University School of Medicine , Incheon, South Korea
                [6 ] Department of Nuclear Medicine, College of Medicine, Dong-A University , Busan, South Korea
                [7 ] Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine and Institute of Convergence Bio-Health , Busan, South Korea
                Author notes
                Correspondence: Kyung Won ParkDepartment of Neurology, College of Medicine Dong-A University , Daesingongwon-ro 26, Seo-gu, Busan602-715, Republic of KoreaTel +8 251 240 2966Fax +8 251 244 8338 Email neuropark@ 123456dau.ac.kr
                Article
                Publisher ID: 200269
                DOI: 10.2147/CIA.S200269
                PMC ID: 6610290
                PubMed ID: 31303750
                SO-VID: fc821eb2-3a87-41ad-8887-30f0df697612
                Copyright © © 2019 Park et al.
                License:

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                Date received : 03 January 2019
                Date accepted : 22 May 2019
                Page count
                Figures: 3, Tables: 3, References: 28, Pages: 9
                Categories
                Subject: Original Research

                ScienceOpen disciplines: Health & Social care
                Keywords: mild cognitive impairment,cognitive training,brain pet
                Data availability:
                ScienceOpen disciplines: Health & Social care
                Keywords: mild cognitive impairment, cognitive training, brain pet

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