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Abstract
Male Wistar rats were intrahippocampally injected with L-fucose and the sugar epitope
2'-fucosyl-lactose prior to induction of long-term potentiation (LTP). Both substances
had only a minimal and short-lasting depressive effect on the monosynaptically evoked
field potential recorded in the dorsal blade of the dentate gyrus of freely moving
rats upon stimulation of the perforant pathway. However, LTP induced by fractionated
tetanization of the perforant pathway, which declined within 24 h in control animals
injected with Lactose, remained at the initial level even 48 h after tetanization
(difference to the control group significant with P < 0.01). The results support earlier
findings which have indicated a participation of fucosylated macromolecules in the
maintenance of LTP. Different molecular mechanisms concerning the effect of both substances
and the significance of the data in elucidation of the relationship between LTP and
memory formation are discussed.