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Abstract
Juvenile hormone (JH) and 20-hydroxyecdysone (20E) are well known to play a gonadotropic
role in adult insects. In Drosophila the mechanism of reciprocal regulation of JH
and 20E is shown to be responsible for their proper balance. Dopamine is a mediator
in this JH and 20E interplay. A proper balance between JH and 20E is crucial for the
normal progress of oogenesis. An imbalance of gonadotropins leads to reproductive
defects: a rise in JH titre leads to oviposition arrest, a rise in 20E level, to the
degradation of vitellogenic oocytes. Upon a change in the level of one of the gonadotropins,
the balance is restored owing to the relative change in the titre of the other.