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Abstract
Fasting has been practiced for millennia, but, only recently, studies have shed light
on its role in adaptive cellular responses that reduce oxidative damage and inflammation,
optimize energy metabolism, and bolster cellular protection. In lower eukaryotes,
chronic fasting extends longevity, in part, by reprogramming metabolic and stress
resistance pathways. In rodents intermittent or periodic fasting protects against
diabetes, cancers, heart disease, and neurodegeneration, while in humans it helps
reduce obesity, hypertension, asthma, and rheumatoid arthritis. Thus, fasting has
the potential to delay aging and help prevent and treat diseases while minimizing
the side effects caused by chronic dietary interventions.