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      New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

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          Most cited references94

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          Wound dressings – a review

          Selvaraj Dhivya, Viswanadha Vijaya Padma, Elango Santhini (2015)
          Wound healing is a dynamic and complex process which requires suitable environment to promote healing process. With the advancement in technology, more than 3000 products have been developed to treat different types of wounds by targeting various aspects of healing process. The present review traces the history of dressings from its earliest inception to the current status and also discusses the advantage and limitations of the dressing materials.
          Article 0 comments Cited 314 times – based on 0 reviews     Review now
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            The Therapeutic Potential of Apigenin

            Bahare Salehi, Alessandro Venditti, Mehdi Sharifi-Rad … (2019)
            Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer’s disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin’s key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.
            Article 0 comments Cited 282 times – based on 0 reviews     Review now
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              Nanoemulsion: Concepts, development and applications in drug delivery.

              Manish Chourasia, Yuvraj Singh, Jaya Meher … (2017)
              Nanoemulsions are biphasic dispersion of two immiscible liquids: either water in oil (W/O) or oil in water (O/W) droplets stabilized by an amphiphilic surfactant. These come across as ultrafine dispersions whose differential drug loading; viscoelastic as well as visual properties can cater to a wide range of functionalities including drug delivery. However there is still relatively narrow insight regarding development, manufacturing, fabrication and manipulation of nanoemulsions which primarily stems from the fact that conventional aspects of emulsion formation and stabilization only partially apply to nanoemulsions. This general deficiency sets up the premise for current review. We attempt to explore varying intricacies, excipients, manufacturing techniques and their underlying principles, production conditions, structural dynamics, prevalent destabilization mechanisms, and drug delivery applications of nanoemulsions to spike interest of those contemplating a foray in this field.
              Article 0 comments Cited 257 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Mol Sci
                Journal ID (iso-abbrev): Int J Mol Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Molecular Sciences
                Publisher: MDPI
                ISSN (Electronic): 1422-0067
                Publication date (Electronic): 08 January 2020
                Publication date Collection: January 2020
                Volume: 21
                Issue: 2
                Electronic Location Identifier: 393
                Affiliations
                [1 ]Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; andre_f_ribeiro@ 123456hotmail.com (A.F.R.); ines.ferreira6556@ 123456gmail.com (M.I.F.); mceuteixeira1@ 123456gmail.com (M.C.T.); lshimojo51@ 123456gmail.com (A.A.M.S.)
                [2 ]CEB—Centre of Biological Engineering, University of Minho, Campus de Gualtar 4710-057 Braga, Portugal
                [3 ]Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, Campinas 13083-852, Brazil
                [4 ]Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain; jlsoriano@ 123456correo.ugr.es (J.L.S.); beatrizclares@ 123456ugr.es (B.C.N.)
                [5 ]CREA—Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy; alessandra.durazzo@ 123456crea.gov.it (A.D.); massimo.lucarini@ 123456crea.gov.it (M.L.)
                [6 ]Department of Endocrinology of Hospital de São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; sbsouto.md@ 123456gmail.com
                [7 ]Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy
                Author notes
                [* ]Correspondence: ebsouto@ 123456ff.uc.pt (E.B.S.); asantini@ 123456unina.it (A.S.); Tel.: +351-239-488-400 (E.B.S.); +039-081-253-9317 (A.S.)
                Author information
                https://orcid.org/0000-0002-9737-6017
                https://orcid.org/0000-0001-9165-1981
                https://orcid.org/0000-0001-5610-1052
                https://orcid.org/0000-0002-5306-1996
                https://orcid.org/0000-0001-9465-0538
                https://orcid.org/0000-0001-6126-7890
                https://orcid.org/0000-0002-7747-9107
                https://orcid.org/0000-0001-5505-3327
                Article
                Publisher ID: ijms-21-00393
                DOI: 10.3390/ijms21020393
                PMC ID: 7013843
                PubMed ID: 31936277
                SO-VID: fbf22047-8a0b-4a0e-9141-74e406169227
                Copyright © © 2020 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 04 October 2019
                Date accepted : 06 January 2020
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular biology
                Keywords: burn wound infection,antibiotics,wound healing,nanoparticles
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: burn wound infection, antibiotics, wound healing, nanoparticles

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